Patterns of Adult Neuromyelitis Optica Spectrum Disorder Patients Compared to Multiple Sclerosis: A Systematic Review and Meta-Analysis.

Autor:	Alqwaifly M; Department of Medicine, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, SAU., Althobaiti AH; Department of Neurology, King Saud Medical City, Riyadh, SAU., AlAibani NS; College of Medicine, Qassim University, Buraydah, SAU., Banjar RZ; College of Medicine, Umm Al-Qura University, Makkah, SAU., Alayed RS; College of Medicine, Qassim University, Buraydah, SAU., Alsubaie SM; College of Medicine, Qassim University, Buraydah, SAU., Alrashed AT; College of Medicine, Almaarefa University, Riyadh, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Oct 24; Vol. 15 (10), pp. e47565. Date of Electronic Publication: 2023 Oct 24 (Print Publication: 2023).
DOI:	10.7759/cureus.47565
Abstrakt:	Neuromyelitis optica spectrum disorders (NMOSDs) are central nervous system inflammatory conditions, now recognized to involve the brain, often identified by aquaporin-4 (AQP4) antibodies. We aimed to summarize the characteristics of adult NMOSD patients compared to multiple sclerosis (MS). A computerized search was conducted on MEDLINE via PubMed, Web of Science, and ProQuest using the relevant keywords. Three independent reviewers performed two-stage screening and data extraction. The Review Manager 5.4 program (Cochrane Collaboration, Windows, London, UK) was used for the analysis. The Joanna Briggs Institute (JIB) tool was used for the quality of included studies. Twenty-three articles were included. NMOSD patients were associated with older age at presentation and higher Expanded Disability Status Scale (MD = 3.88, 95% CI: 1.80 to 5.97, P = 0.0003) and (MD = 1.15, 95% CI: 0.58 to 1.72, P < 0.0001), respectively. The risk of NMOSD in females was significantly higher than MS (OR = 2.21, 95% CI: 1.41 to 3.46, P = 0.0005). Patients with NMOSD were associated with a lower risk of extrapyramidal symptoms (OR = 0.26, 95% CI: 0.11 to 0.60, P < 0.01), brainstem involvement symptoms (OR = 0.32, 95% CI: 0.16 to 0.64, P < 0.01), and developing brain lesions compared to MS (OR = 0.08, 95% CI: 0.03 to 0.18, P < 0.00001). The current evidence suggests that both NMOSD and MS have different demographic, clinical, and lesion characteristics. There is a need for additional validation of the identified differences compared with MS due to the lack of long-term systematic imaging investigations in NMOSD. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Alqwaifly et al.)
Databáze:	MEDLINE
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