Assembly of fluorophore J-aggregates with nanospacer onto mesoporous nanoparticles for enhanced photoacoustic imaging.
| Autor: | Xu W; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland., Leskinen J; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland., Sahlström T; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland., Happonen E; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland., Tarvainen T; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland., Lehto VP; Department of Technical Physics, University of Eastern Finland, 70210 Kuopio, Finland. |
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| Jazyk: | angličtina |
| Zdroj: | Photoacoustics [Photoacoustics] 2023 Aug 28; Vol. 33, pp. 100552. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023). |
| DOI: | 10.1016/j.pacs.2023.100552 |
| Abstrakt: | Many fluorophores, such as indocyanine green (ICG), have poor photostability and low photothermal efficiency hindering their wide application in photoacoustic (PA) tomography. In the present study, a supramolecular assembly approach was used to develop the hybrid nanoparticles (Hy NPs) of ICG and porous silicon (PSi) as a novel contrast agent for PA tomography. ICG was assembled on the PSi NPs to form J-aggregates within 30 min. The Hy NPs presented a red-shifted absorption, improved photothermal stability, and enhanced PA performance. Furthermore, 1-dodecene (DOC) was assembled into the NPs as a 'nanospacer', which enhanced non-radiative decay for increased thermal release. Compared to the Hy NPs, adding DOC into the Hy NPs (DOC-Hy) increased the PA signal by 83%. Finally, the DOC-Hy was detectable in PA tomography at 1.5 cm depth in tissue phantom even though its concentration was as low as 6.25 µg/mL, indicating the potential for deep tissue PA imaging. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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