Enhancers dysfunction in the 3D genome of cancer cells.
| Autor: | Della Chiara G; Human Technopole, Milan, Italy., Jiménez C; Human Technopole, Milan, Italy., Virdi M; Human Technopole, Milan, Italy., Crosetto N; Human Technopole, Milan, Italy.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.; Science for Life Laboratory, Solna, Sweden., Bienko M; Human Technopole, Milan, Italy.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.; Science for Life Laboratory, Solna, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Nov 06; Vol. 11, pp. 1303862. Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023). |
| DOI: | 10.3389/fcell.2023.1303862 |
| Abstrakt: | Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and tissue homeostasis. Hence, it is of no surprise that mis-regulation of genome architecture through rearrangements of the linear genome sequence or epigenetic perturbations are often linked to aberrant gene expression programs in tumor cells. Increasing research efforts have shed light into the causes and consequences of alterations of 3D genome organization. In this review, we summarize the current knowledge on how 3D genome architecture is dysregulated in cancer, with a focus on enhancer highjacking events and their contribution to tumorigenesis. Studying the functional effects of genome architecture perturbations on gene expression in cancer offers a unique opportunity for a deeper understanding of tumor biology and sets the basis for the discovery of novel therapeutic targets. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Della Chiara, Jiménez, Virdi, Crosetto and Bienko.) |
| Databáze: | MEDLINE |
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