Progress in cancer neuroscience.

Autor: Lan YL; Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou Zhejiang China.; Clinical Research Center for Neurological Diseases of Zhejiang Province Hangzhou China., Zou S; Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science Zhejiang Chinese Medical University Hangzhou China., Wang W; Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing China., Chen Q; Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science Zhejiang Chinese Medical University Hangzhou China., Zhu Y; Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China.; Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou Zhejiang China.; Clinical Research Center for Neurological Diseases of Zhejiang Province Hangzhou China.
Jazyk: angličtina
Zdroj: MedComm [MedComm (2020)] 2023 Nov 22; Vol. 4 (6), pp. e431. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).
DOI: 10.1002/mco2.431
Abstrakt: Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor-associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the "wireless communications" between nervous system and cancer. Finally, promising future strategies targeting neuronal-brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies.
Competing Interests: No potential conflict of interest were reported by the authors.
(© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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