Most bothersome symptom in migraine and probable migraine: A population-based study.

Autor: Kim SJ; Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Lee HJ; Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.; Department of Neurology, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Gyeonggi-do, Korea., Lee SH; Department of Neurology, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea., Cho S; Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Kim KM; Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Chu MK; Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Nov 29; Vol. 18 (11), pp. e0289729. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0289729
Abstrakt: Recently, the most bothersome symptom has been recommended as a co-primary endpoint in clinical trials on the acute treatment of migraine. Probable migraine is a subtype of migraine that fulfills all but one criterion for migraine diagnosis. We aimed to compare the most bothersome symptom between probable migraine and migraine. This study analyzed data from a nationwide study conducted in Korea, and the most bothersome symptom was assessed by requesting the participants to select one of the four typical accompanying symptoms of migraine. Responses to acute treatment were evaluated using the migraine Treatment Optimization Questionnaire-6. Nausea was the most bothersome symptom, followed by phonophobia and vomiting in the migraine group (nausea, 61.8%; phonophobia, 25.3%; vomiting, 10.0%; and photophobia, 2.9%) and the probable migraine group (nausea, 82.2%; phonophobia, 9.5%; vomiting, 5.6%; and photophobia, 2.7%). In participants with migraine, vomiting (adjusted odds ratio = 6.513; 95% confidence interval, 1.763-24.057) and phonophobia (adjusted odds ratio = 0.437; 95% confidence interval, 0.206-0.929) were significantly associated with severe headache intensity and nausea was significantly associated with >3 headache days per 30 days (adjusted odds ratio = 0.441; 95% confidence, 0.210-0.927). Different patterns of associations were observed in probable migraine.
Competing Interests: M.K.C. was a site investigator for a multicenter trial sponsored by Biohaven Pharmaceuticals, Allergan Korea, and Ildong Pharmaceutical Company. He received lecture honoraria from Eli Lilly and Company, Handok-Teva, and Ildong Pharmaceutical Company over the past 24 months. He received grants from Yonsei University College of Medicine (6-2021-0229), the Korea Health Industry Development Institute (KHIDI) (Grant No.: HV22C0106), and a National Research Foundation of Korea (NRF) grant from the Korean government (MSIT) (2022R1A2C1091767). No other authors possess competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje