Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation.

Autor:	Guyonnet E; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada., Kim SJ; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Xia YY; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Giannakeas V; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; ICES, Toronto, Ontario, Canada., Lubinski J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Randall Armel S; Bhalwani Familial Cancer Clinic, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.; Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada., Eisen A; Toronto-Sunnybrook Regional Cancer Center, Toronto, Canada., Bordeleau L; Department of Oncology, Juravinski Cancer Centre, Hamilton, Canada., Eng C; Genomic Medicine Institute, Center for Personalised Genetic Healthcare, Cleveland Clinic, Cleveland, Ohio., Olopade OI; Department of Medicine and Human Genetics, University of Chicago, Chicago, Illinois., Tung N; Beth Israel Deaconess Medical Center, Boston, Massachusetts., Foulkes WD; Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada., Couch FJ; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Aeilts AM; Division of Human Genetics, Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, Ohio., Narod SA; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Kotsopoulos J; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Cancer research communications [Cancer Res Commun] 2023 Nov 28; Vol. 3 (11), pp. 2420-2429.
DOI:	10.1158/2767-9764.CRC-23-0223
Abstrakt:	In the general population, physical activity has been associated with a lower risk of several cancers; however, the evidence for ovarian cancer is not clear. It is suggested that early-life physical activity may differentially impact risk. Whether this is true among women at high risk due to a pathogenic variant (mutation) in the BRCA1 or BRCA2 genes has not been evaluated. Thus, we performed a matched case-control study to evaluate the association between adolescent and early-adulthood physical activity and ovarian cancer. BRCA mutation carriers who completed a research questionnaire on various exposures and incident disease and with data available on physical activity were eligible for inclusion. Self-reported activity at ages 12-13, 14-17, 18-22, 23-29, and 30-34 was used to calculate the average metabolic equivalent of task (MET)-hours/week for moderate, vigorous, and total physical activity during adolescence (ages 12-17) and early-adulthood (ages 18-34). Conditional logistic regression was used to estimate the OR and 95% confidence intervals (CI) of invasive ovarian cancer associated with physical activity. This study included 215 matched pairs (mean age = 57.3). There was no association between total physical activity during adolescence (ORhigh vs. low = 0.91; 95% CI: 0.61-1.36; Ptrend = 0.85), early-adulthood (ORhigh vs. low = 0.78; 95% CI: 0.51-1.20; Ptrend = 0.38) and overall (ORhigh vs. low = 0.81; 95% CI: 0.54-1.23; Ptrend = 0.56) and ovarian cancer. Findings were similar for moderate (Ptrend ≥ 0.25) and vigorous (Ptrend ≥ 0.57) activity. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, physical activity should continue to be encouraged to promote overall health. Significance: In this matched case-control study, we observed no association between physical activity during adolescence or early-adulthood and subsequent risk of ovarian cancer. These findings do not provide evidence for an association between early-life physical activity and BRCA-ovarian cancer; however, being active remains important to promote overall health and well-being. (© 2023 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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