Anticancer actions of carnosine in cellular models of prostate cancer.

Autor: Habra K; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Chemistry Department, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Pearson JRD; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Systems Health and integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK., Le Vu P; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Puig-Saenz C; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Systems Health and integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK., Cripps MJ; Centre for Diabetes, Chronic Diseases, and Ageing, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Khan MA; Department of Urology, University Hospitals of Leicester NHS Trust, Leicester, UK., Turner MD; Centre for Systems Health and integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Diabetes, Chronic Diseases, and Ageing, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Sale C; Institute of Sport, Manchester Metropolitan University, Manchester, UK., McArdle SEB; John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.; Centre for Systems Health and integrated Metabolic Research (SHiMR), School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Jazyk: angličtina
Zdroj: Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Jan; Vol. 28 (2), pp. e18061. Date of Electronic Publication: 2023 Nov 29.
DOI: 10.1111/jcmm.18061
Abstrakt: Treatments for organ-confined prostate cancer include external beam radiation therapy, radical prostatectomy, radiotherapy/brachytherapy, cryoablation and high-intensity focused ultrasound. None of these are cancer-specific and are commonly accompanied by side effects, including urinary incontinence and erectile dysfunction. Moreover, subsequent surgical treatments following biochemical recurrence after these interventions are either limited or affected by the scarring present in the surrounding tissue. Carnosine (β-alanyl-L-histidine) is a histidine-containing naturally occurring dipeptide which has been shown to have an anti-tumorigenic role without any detrimental effect on healthy cells; however, its effect on prostate cancer cells has never been investigated. In this study, we investigated the effect of carnosine on cell proliferation and metabolism in both a primary cultured androgen-resistant human prostate cancer cell line, PC346Flu1 and murine TRAMP-C1 cells. Our results show that carnosine has a significant dose-dependent inhibitory effect in vitro on the proliferation of both human (PC346Flu1) and murine (TRAMP-C1) prostate cancer cells, which was confirmed in 3D-models of the same cells. Carnosine was also shown to decrease adenosine triphosphate content and reactive species which might have been caused in part by the increase in SIRT3 also shown after carnosine treatment. These encouraging results support the need for further human in vivo work to determine the potential use of carnosine, either alone or, most likely, as an adjunct therapy to surgical or other conventional treatments.
(© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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