A robust treatment planning approach for chest motion in postmastectomy chest wall intensity modulated radiation therapy.

Autor: Miyasaka Y; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Ono T; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Chai H; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Souda H; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Lee SH; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Ishizawa M; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan., Akamatsu H; Department of Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan., Sato H; Department of Radiology, Yamagata University Faculty of Medicine, Yamagata, Japan., Iwai T; Department of Heavy Particle Medical Science, Yamagata University Graduate School of Medical Science, Yamagata, Japan.
Jazyk: angličtina
Zdroj: Journal of applied clinical medical physics [J Appl Clin Med Phys] 2024 Jan; Vol. 25 (1), pp. e14217. Date of Electronic Publication: 2023 Nov 29.
DOI: 10.1002/acm2.14217
Abstrakt: Purpose: Chest wall postmastectomy radiation therapy (PMRT) should consider the effects of chest wall respiratory motion. The purpose of this study is to evaluate the effectiveness of robustness planning intensity modulated radiation therapy (IMRT) for respiratory movement, considering respiratory motion as a setup error.
Material and Methods: This study analyzed 20 patients who underwent PMRT (10 left and 10 right chest walls). The following three treatment plans were created for each case and compared. The treatment plans are a planning target volume (PTV) plan (PP) that covers the PTV within the body contour with the prescribed dose, a virtual bolus plan (VP) that sets a virtual bolus in contact with the body surface and prescribing the dose that includes the PTV outside the body contour, and a robust plan (RP) that considers respiratory movement as a setup uncertainty and performs robust optimization. The isocenter was shifted to reproduce the chest wall motion pattern and the doses were recalculated for comparison for each treatment plan.
Result: No significant difference was found between the PP and the RP in terms of the tumor dose in the treatment plan. In contrast, VP had 3.5% higher PTV Dmax and 5.5% lower PTV V95% than RP (p < 0.001). The RP demonstrated significantly higher lung V20Gy and Dmean by 1.4% and 0.4 Gy, respectively, than the PP. The RP showed smaller changes in dose distribution affected by chest wall motion and significantly higher tumor dose coverage than the PP and VP.
Conclusion: We revealed that the RP demonstrated comparable tumor doses to the PP in treatment planning and was robust for respiratory motion compared to both the PP and the VP. However, the organ at risk dose in the RP was slightly higher; therefore, its clinical use should be carefully considered.
(© 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.)
Databáze: MEDLINE
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