Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses.
| Autor: | Jager MC; Cornell University, Ithaca, NY., Choi E; University of California, Davis, Davis, CA., Tomlinson JE; Cornell University, Ithaca, NY., Van de Walle G; Cornell University, Ithaca, NY. |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary pathology [Vet Pathol] 2024 May; Vol. 61 (3), pp. 442-452. Date of Electronic Publication: 2023 Nov 29. |
| DOI: | 10.1177/03009858231214024 |
| Abstrakt: | Equine parvovirus-hepatitis (EqPV-H) is the causative agent of Theiler's disease, or severe acute hepatic necrosis, in horses. However, it is poorly understood whether EqPV-H is associated with other histologic findings in horses with clinical liver disease. The objective of this study was to examine the prevalence and severity of EqPV-H infections in diagnostic liver samples. Archived formalin-fixed, paraffin-embedded (FFPE) liver samples ( n = 98) from Cornell University and University of California, Davis, collected between 2007 and 2022 were evaluated for 15 individual histologic features and by EqPV-H in situ hybridization. EqPV-H was detected in 48% ( n = 47) of samples. The most common histologic features of EqPV-H-positive samples included individual hepatocyte death ( n = 40, 85%), lobular infiltrates ( n = 38, 80%), portal infiltrates ( n = 35, 74%), and ductular reaction ( n = 33, 70%). Centrilobular necrosis, portal infiltrate, and individual hepatocyte death were positively associated with high viral load. Neutrophil infiltrates, bridging fibrosis, and portal edema were negatively associated with a high viral load. Only 4 of 49 tested samples were positive for equine hepacivirus by polymerase chain reaction (PCR), but the PCR assay was unreliable for FFPE tissues. In summary, this study demonstrates that EqPV-H is common in a variety of liver pathologies and should be considered as a differential diagnosis in cases of hepatitis other than Theiler's disease. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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