A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine.

Autor: Ahn DB; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea.; Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, South Korea., Jang HB; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea.; Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu, South Korea., Ryu Y; Korean Medicine Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea., Kim HK; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea., Guan X; Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing, China., Fan Y; Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing, China., Lee BH; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea., Kim HY; Department of Physiology, Yonsei University College of Medicine, Seoul, South Korea.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2023 Dec; Vol. 28 (12), pp. e13354.
DOI: 10.1111/adb.13354
Abstrakt: Administration of cocaine increases synaptic dopamine levels by blocking dopamine reuptake and leads to increased locomotor activity and compulsive drug-seeking behaviour. It has been suggested that the lateral hypothalamus (LH) or lateral habenula (LHb) is involved in drug-seeking behaviours. To explore the role of the LH and the LHb in cocaine-induced psychomotor responses, we tested whether modulation of the LH or the LH-LHb circuit affects cocaine-induced locomotion. Cocaine-induced locomotor activity and dopamine release were suppressed by the activation of the LH with 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide (PEPA), an AMPA receptor agonist. When the LH was inhibited by microinjection of a GABA receptor agonists mixture prior to cocaine injection, the cocaine's effects were enhanced. Furthermore, optogenetic activation of the LH-LHb circuit attenuated the cocaine-induced locomotion, while optogenetic inhibition of the LH-LHb circuit increased it. In vivo extracellular recording found that the LH sent a glutamatergic projection to the LHb. These findings suggest that the LH glutamatergic projection to the LHb plays an active role in the modulation of cocaine-induced psychomotor responses.
(© 2023 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
Databáze: MEDLINE
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