Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study.

Autor:	Enebe JT; Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine/Teaching Hospital, Parklane, Enugu, Nigeria., Enebe NO; Department of Community Medicine, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria., Nwagha TU; Department of Haematology and Immunology, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria.; Department of Haematology and Immunology, College of Medicine, Ituku Ozalla Campus, Enugu, Nigeria., Meka IA; Department of Chemical Pathology, College of Medicine, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria., Nwankwo ME; Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine/Teaching Hospital, Parklane, Enugu, Nigeria., Izuka EO; Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria., Egede JO; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Ugwu IA; Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine/Teaching Hospital, Parklane, Enugu, Nigeria., Okoro NI; Department of Chemical Pathology, College of Medicine, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria., Okoye HC; Department of Haematology and Immunology, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria., Iyoke CA; Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Ituku/Ozalla Campus, Enugu State, Nigeria.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2023 Nov; Vol. 51 (11), pp. 3000605231213265.
DOI:	10.1177/03000605231213265
Abstrakt:	Objective: To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria. Methods: This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined. Results: A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants. Conclusion: Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women. Competing Interests: Declaration of conflicting interestsThe authors declare that there are no conflicts of interest.
Databáze:	MEDLINE
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