Thinning of compact layer and systolic dysfunction in isolated left ventricular non-compaction: A cardiac magnetic resonance study.

Autor: De Lazzari M; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Brunetti G; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Frasson E; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Zorzi A; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Cipriani A; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Migliore F; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., De Conti G; Department of Medicine, University of Padua, Italy., Motta R; Department of Medicine, University of Padua, Italy., Perazzolo Marra M; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy., Corrado D; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy. Electronic address: domenico.corrado@unipd.it.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2024 Feb 15; Vol. 397, pp. 131614. Date of Electronic Publication: 2023 Nov 26.
DOI: 10.1016/j.ijcard.2023.131614
Abstrakt: Background: The Petersen' index reflects an excess of myocardial trabeculation which is not a specific morpho-functional feature of left ventricular non-compaction (LVNC) cardiomyopathy, but a "phenotypic trait" even observed in association with other myocardial diseases and over-loading conditions. The present study was designed to evaluate the relation between a critical thinning of compact layer and the development of systolic dysfunction and LVNC cardiomyopathy.
Methods: We compared CMR morpho-functional features and measurements of LV wall thickness using a 17 segment model of a cohort of patients fulfilling the Petersen criterion for LVNC with LV systolic dysfunction versus those of a cohort of age- and sex-matched controls with LVNC and preserved LV systolic function. All the study patients had an "isolated" LVNC defined as positive Petersen criterion in the absence of other diseases such as hypertrophic and dilated cardiomyopathy, valvular heart disease, or congenital heart disease and over-loading conditions.
Results: he study population included 33 patients with "isolated" LVNC: 11 consecutive index patients with a reduced LV ejection fraction (LVNCrEF) and 22 controls with a preserved LVEF (LVNCpEF). The compact myocardial layer was thinner in patients with LVNCrEF than in those with LVNCpEF patients, both in mid-ventricular and apical LV segments. On linear regression analysis, there was a linear correlation between median thickness of mid-ventricular free wall segments and left ventricular ejection fraction (r = 0.51, p = 0.005). On the ROC curves analysis, ≥2 segments with a compact myocardial layer <5 mm in the free wall mid-ventricular segments showed the best accuracy for reduced LVEF (100% sensitivity and 60% specificity; AUC 0.81, p < 0.01). The negative predictive value for LV systolic dysfunction of <2 free wall mid ventricular segments <5 mm was 100%. On quantitative analysis, the mass of papillary muscles was lower in patients with LVNCrEF [1.2 (0.8-1.4) versus 1.6 (1.1-1.8) g/mq; p = 0.08].
Conclusions: A thinned compact layer of mid-ventricular segments of the LV free wall was associated with a reduced systolic function and "isolated" LVNC cardiomyopathy.
Competing Interests: Declaration of Competing Interest No disclosures.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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