Zeolitic imidazole framework-8 loaded gelatin methacryloyl microneedles: A transdural and controlled-release drug delivery system attenuates neuroinflammation after spinal cord injury.

Autor: Chen K; Department of Orthopedics, Shanghai Changhai Hospital, Shanghai 200433, China. Electronic address: spine_kai@smmu.edu.cn., Li B; Department of Orthopedics, Shanghai Changhai Hospital, Shanghai 200433, China. Electronic address: smmulibo@163.com., Xu H; Department of Infectious Disease, Shanghai Changhai Hospital, Shanghai 200433, China. Electronic address: boyhaw@163.com., Wu J; Basic Medicine College, Naval Medical University, Shanghai 200433, China. Electronic address: 18785262336@163.com., Li J; Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Electronic address: lijianhua317@tom.com., Sun W; Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Electronic address: drsunwuquan@126.com., Fang M; Department of Tuina, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Electronic address: fm-tn0510@shutcm.edu.cn., Wang W; Department of Otolaryngology-Head and Neck Surgery, Shanghai, Changhai Hospital, Shanghai 200433, China. Electronic address: wangw0503@163.com., Wang S; School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China. Electronic address: sgwang@usst.edu.cn., Zhai X; Department of Orthopedics, Shanghai Changhai Hospital, Shanghai 200433, China. Electronic address: drzhaixiao@126.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 256 (Pt 1), pp. 128388. Date of Electronic Publication: 2023 Nov 26.
DOI: 10.1016/j.ijbiomac.2023.128388
Abstrakt: Spinal cord injury (SCI) is a matter of significant clinical concern, often treated through early surgical decompression along with methylprednisolone sodium succinate (MPSS). However, the side effects and the unsatisfactory focal concentration of MPSS have limited its further applications. To address this limitation, herein, a versatile drug delivery system of zeolitic imidazole framework-8 (ZIF-8) and gelatin methacryloyl microneedles (GelMA MNs) was developed for stable, transdural, and controlled sustained release of drugs in SCI. The microneedles were used to create tiny pores in the dura mater, allowing for the direct administration of drugs into the spinal cord. ZIF-8 provided a secondary extended release once they were separated from the microneedles. To attenuate the neuroinflammation, MPSS was selected. Such a combination of ZIF-8 and GelMA MNs was able to prolong the release period of MPSS to five days. The system showed transdural capacity, reduction of M 1 polarization, and decrease in NLRP3-positive inflammasome and proinflammatory cytokines. In vivo studies indicated that this novel drug delivery strategy could constrict the inflammatory microenvironment, reduce glial scar formation, and promote neural regeneration. Thus, this versatile drug delivery system provides an up-and-coming alternative for stable, transdural, and controlled sustained release of drugs to those suffering from SCI.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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