Recent Advances in Mesenchymal Stem/Stromal Cell-Based Therapy for Alcohol-Associated Liver Disease and Non-alcoholic Fatty Liver Disease.

Autor:	Korkida F; Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece., Stamatopoulou A; Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece., Roubelakis MG; Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.; Cell and Gene Therapy Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece.
Jazyk:	angličtina
Zdroj:	Stem cells translational medicine [Stem Cells Transl Med] 2024 Feb 14; Vol. 13 (2), pp. 107-115.
DOI:	10.1093/stcltm/szad082
Abstrakt:	Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) represent pathological conditions that include many distinct stages, potentially leading to the final stage of cirrhotic liver. To date, liver transplantation is the sole successful treatment with concomitant limitations related to donor organ shortage and the need of life-long immunosuppressive therapy. Recently, cell-based therapies for ALD and NAFLD have been proposed with mesenchymal stem/stromal cells (MSCs) as promising effectors. MSC therapeutic applications offer hepatoprotection, regulation of the inflammatory process and angiogenesis particularly in ALD and NAFLD pre-clinical disease models. Recent studies suggested that hepatospecific MSC-based therapies could benefit liver diseases by restoring liver function and decreasing inflammation and fibrosis. Similarly to solid-organ transplantation, limitations in MSC approaches include donor availability exacerbated by high number of cells and cell trapping into lungs. Herein, based on recent advances, we discuss the use of MSCs as a therapeutic approach for ALD and NAFLD and we provide the available information for the establishment of a framework toward a potential clinical application. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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