Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.

Autor:	Antoni S; Department of Immunization, Vaccines and Biologicals, World Health Organization Headquarters, Geneva, Switzerland., Nakamura T; Department of Immunization, Vaccines and Biologicals, World Health Organization Headquarters, Geneva, Switzerland.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan., Cohen AL; Department of Immunization, Vaccines and Biologicals, World Health Organization Headquarters, Geneva, Switzerland., Mwenda JM; World Health Organization, Regional Office for Africa, Brazzaville, Congo., Weldegebriel G; World Health Organization, Inter Country Support Team, Harare, Zimbabwe., Biey JNM; World Health Organization, Inter Country Support Team, Ouagadougou, Burkina Faso., Shaba K; World Health Organization, Regional Office for Africa, Brazzaville, Congo., Rey-Benito G; Pan American Health Organization, World Health Organization, Washington District of Columbia, Washington, DC, United States of America., de Oliveira LH; Pan American Health Organization, World Health Organization, Washington District of Columbia, Washington, DC, United States of America., Oliveira MTDC; Pan American Health Organization, World Health Organization, Washington District of Columbia, Washington, DC, United States of America., Ortiz C; Pan American Health Organization, World Health Organization, Washington District of Columbia, Washington, DC, United States of America., Ghoniem A; World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt., Fahmy K; World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt., Ashmony HA; World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt., Videbaek D; World Health Organization, Regional Office for Europe, Copenhagen, Denmark., Daniels D; World Health Organization, Regional Office for Europe, Copenhagen, Denmark., Pastore R; World Health Organization, Regional Office for Europe, Copenhagen, Denmark., Singh S; World Health Organization, Regional Office for Europe, Copenhagen, Denmark., Tondo E; World Health Organization, Regional Office for South East Asia, Delhi, India., Liyanage JBL; World Health Organization, Regional Office for South East Asia, Delhi, India., Sharifuzzaman M; World Health Organization, Regional Office for South East Asia, Delhi, India., Grabovac V; World Health Organization, Regional Office for the Western Pacific, Manila, Philippines., Batmunkh N; World Health Organization, Regional Office for the Western Pacific, Manila, Philippines., Logronio J; World Health Organization, Regional Office for the Western Pacific, Manila, Philippines., Armah G; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Dennis FE; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Seheri M; World Health Organization Regional Reference Laboratory for Rotavirus, Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Magagula N; World Health Organization Regional Reference Laboratory for Rotavirus, Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Mphahlele J; World Health Organization Regional Reference Laboratory for Rotavirus, Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Leite JPG; Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Araujo IT; Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Fumian TM; Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., El Mohammady H; Bacterial and Parasitic Diseases Research Program, U.S. Naval Medical Research Unit-3, Cairo, Egypt., Semeiko G; Republican Research and Practical Center for Epidemiology and Microbiology, Minsk, Belarus., Samoilovich E; Republican Research and Practical Center for Epidemiology and Microbiology, Minsk, Belarus., Giri S; Division of Gastrointestinal Sciences, The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India., Kang G; Division of Gastrointestinal Sciences, The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, India., Thomas S; Enteric Diseases Group Murdoch Children's Research Institute, Department of Paediatrics University of Melbourne, Parkville, Victoria, Australia., Bines J; Enteric Diseases Group Murdoch Children's Research Institute, Department of Paediatrics University of Melbourne, Parkville, Victoria, Australia., Kirkwood CD; Enteric Diseases Group Murdoch Children's Research Institute, Department of Paediatrics University of Melbourne, Parkville, Victoria, Australia., Liu N; National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China., Lee DY; Division of Viral Diseases, Bureau of Infectious Diseases Diagnosis Control, Korea Diseases Control and Prevention Agency, Osong, Korea., Iturriza-Gomara M; Centre for Vaccine Innovation and Access, PATH, Geneva, Switzerland., Page NA; National Institute for Communicable Diseases, Centre for Enteric Disease, Johannesburg, South Africa.; Faculty of Health Sciences, Department of Medical Virology, University of Pretoria, Arcadia, Pretoria, South Africa., Esona MD; Centers for Disease Control and Prevention, Atlanta, Georgia., Ward ML; Centers for Disease Control and Prevention, Atlanta, Georgia., Wright CN; Centers for Disease Control and Prevention, Atlanta, Georgia., Mijatovic-Rustempasic S; Centers for Disease Control and Prevention, Atlanta, Georgia., Tate JE; Centers for Disease Control and Prevention, Atlanta, Georgia., Parashar UD; Centers for Disease Control and Prevention, Atlanta, Georgia., Gentsch J; Retired Researcher, West Newton, Pennsylvania, United States of America., Bowen MD; Centers for Disease Control and Prevention, Atlanta, Georgia., Serhan F; Department of Immunization, Vaccines and Biologicals, World Health Organization Headquarters, Geneva, Switzerland.
Jazyk:	angličtina
Zdroj:	PLOS global public health [PLOS Glob Public Health] 2023 Nov 28; Vol. 3 (11), pp. e0001358. Date of Electronic Publication: 2023 Nov 28 (Print Publication: 2023).
DOI:	10.1371/journal.pgph.0001358
Abstrakt:	Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease burden but may also be changing the rotavirus genetic landscape and driving the emergence of new genotypes. We report genotype data of more than 16,000 rotavirus isolates from 40 countries participating in the Global Rotavirus Surveillance Network. Data from a convenience sample of children under five years of age hospitalized with acute watery diarrhea who tested positive for rotavirus were included. Country results were weighted by their estimated rotavirus disease burden to estimate regional genotype distributions. Globally, the most frequent genotypes identified after weighting were G1P[8] (31%), G1P[6] (8%) and G3P[8] (8%). Genotypes varied across WHO Regions and between countries that had and had not introduced rotavirus vaccine. G1P[8] was less frequent among African (36 vs 20%) and European (33 vs 8%) countries that had introduced rotavirus vaccines as compared to countries that had not introduced. Our results describe differences in the distribution of the most common rotavirus genotypes in children with diarrhea in low- and middle-income countries. G1P[8] was less frequent in countries that had introduced the rotavirus vaccine while different strains are emerging or re-emerging in different regions. Competing Interests: The authors have declared that no competing interests exist. (Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)
Databáze:	MEDLINE
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