The descriptive epidemiology of melanoma in Italy has changed - for the better.

Autor: Bucchi L; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Mancini S; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy - silvia.mancini@irst.emr.it., Crocetti E; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Dal Maso L; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Pordenone, Italy., Baldacchini F; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Vattiato R; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Giuliani O; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Ravaioli A; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Zamagni F; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Bella F; Siracusa Cancer Registry, Azienda Sanitaria Provinciale (ASP), Siracusa, Italy., Bidoli E; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Pordenone, Italy., Caldarella A; Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Candela G; Trapani Cancer Registry, Department of Prevention, Servizio Sanitario Regionale Sicilia, Azienda Sanitaria Provinciale (ASP), Trapani, Italy., Carone S; Taranto Cancer Registry, Unit of Statistics and Epidemiology, ASL Taranto, Taranto, Italy., Carrozzi G; Department of Public Health, ASL Modena, Modena, Italy., Cavallo R; Cancer Registry - ASL Salerno, Salerno, Italy., Ferrante M; Integrated Cancer Registry of Catania-Messina-Enna, Rodolico-San Marco Polyclinic University Hospital, Catania, Italy., Ferretti S; Romagna Cancer Registry - Section of Ferrara, ASL Ferrara, University of Ferrara, Ferrara, Italy., Filiberti RA; Liguria Cancer Registry, San Martino Polyclinic Hospital IRCCS, Genoa, Italy., Fusco M; Napoli3 Sud Cancer Registry, Naples, Italy., Gatti L; Mantova Cancer Registry, Epidemiology Unit, Agenzia di Tutela della Salute (ATS) della Val Padana, Mantua, Italy., Gili A; Department of Experimental Medicine, University of Perugia, Perugia, Italy., Iacovacci S; Latina Cancer Registry, Lazio, Italy., Magoni M; Registry of Brescia Province, Epidemiology Unit, Brescia Health Protection Agency, Brescia, Italy., Mangone L; Epidemiology Unit, AUSL - IRCCS di Reggio Emilia, Reggio Emilia, Italy., Mazzoleni G; South-Tyrol Tumor Registry, Bolzano, Italy., Michiara M; Parma Cancer Registry, Medical Oncology Unit, Parma University Hospital, Parma, Italy., Musolino A; Department of Medicine and Surgery, University of Parma, Parma, Italy.; Medical Oncology Unit and Cancer Registry, Parma University Hospital, Parma, Italy., Piffer S; Trento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy., Piras D; Sassari Cancer Registry, Azienda Regionale per la Tutela della Salute (ATS), Sassari, Italy., Rizzello RV; Trento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy., Rosso S; Piedmont Cancer Registry, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Rugge M; Veneto Tumor Registry, Azienda Zero, Padua, Italy., Scala U; Cancer Registry - ASL Salerno, Salerno, Italy., Stracci F; Umbria Cancer Registry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Tagliabue G; Lombardy Cancer Registry of Varese Province, Cancer Registry Unit, Department of Research, National Cancer Institute IRCCS Foundation, Milan, Italy., Toffolutti F; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Pordenone, Italy., Tumino R; Cancer Registry, Department of Histopathology, Provincial Health Authority (ASP), Ragusa, Italy., Biggeri A; Unit of Biostatistics, Epidemiology, and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy., Masini C; Unit of Oncological Pharmacy, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Ridolfi L; Department of Immunotherapy, Cell Therapy and Biobank, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy., Villani S; Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy., Palmieri G; Department of Immuno-oncology and Targeted Oncologic Biotherapies, University of Sassari, Sassari, Italy.; Unit of Tumor Genetics, IRGB-CNR, Sassari, Italy., Stanganelli I; Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy., Falcini F; Romagna Cancer Registry, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì-Cesena, Italy.; Cancer Prevention Unit, ASL Forlì, Forlì-Cesena, Italy.
Jazyk: angličtina
Zdroj: Italian journal of dermatology and venereology [Ital J Dermatol Venerol] 2023 Dec; Vol. 158 (6), pp. 483-492.
DOI: 10.23736/S2784-8671.23.07653-3
Abstrakt: A recent research project using data from a total of 40 cancer registries has provided new epidemiologic insights into the results of efforts for melanoma control in Italy between the 1990s and the last decade. In this article, the authors present a summary and a commentary of their findings. Incidence increased significantly throughout the study period in both sexes. However, the rates showed a stabilization or a decrease in men and women aged below 35 years. The risk of disease increased for successive cohorts born until 1973 (women) and 1975 (men) while subsequently tending to decline. The trend towards decreasing tumor thickness and increasing survival has continued, but a novel favorable prognostic factor has emerged since 2013 for patients - particularly for males - with thick melanoma, most likely represented by molecular targeted therapies and immune checkpoint inhibitors. Due to this, the survival gap between males and females has been filled out. In the meanwhile, and despite the incidence increase, dermatologists have not lowered their threshold to perform skin biopsy. Skin biopsy rate has increased because of the increasingly greater volume of dermatologic office visits, but the proportion of skin biopsies out of dermatologic office visits has remained constant. In summary, an important breakthrough in melanoma control in Italy has taken place. Effective interventions have been implemented across the full scope of care, which involve many large local populations - virtually the whole national population. The strategies adopted during the last three decades represent a valuable basis for further steps ahead in melanoma control in Italy.
Databáze: MEDLINE
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