Patients with periodontitis might increase the risk of urologic cancers: a bidirectional two-sample Mendelian randomization study.

Autor: Li B; Health Management Center, General Practice Medical Center, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.; West China School of Public Health, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China., Lin Y; Health Management Center, General Practice Medical Center, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China., Yang Y; Health Management Center, General Practice Medical Center, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China., Wang Z; Engineering Research Center of Medical Information Technology, Ministry of Education, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China., Shi R; Engineering Research Center of Medical Information Technology, Ministry of Education, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China., Zheng T; Engineering Research Center of Medical Information Technology, Ministry of Education, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China., Liao B; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan, 610044, People's Republic of China. 11511761@qq.com., Liao G; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. liaoga@hotmail.com., Huang J; Health Management Center, General Practice Medical Center, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. michael_huangjin@163.com.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2024 Apr; Vol. 56 (4), pp. 1243-1251. Date of Electronic Publication: 2023 Nov 28.
DOI: 10.1007/s11255-023-03858-w
Abstrakt: Background: Numerous observational epidemiological studies have reported a bidirectional relationship between periodontitis and urological cancers. However, the causal link between these two phenotypes remains uncertain. This study aimed to examine the bidirectional causal association between periodontitis and four types of urological tumors, specifically kidney cancer (KC), prostate cancer (PC), bladder cancer (BC), and testis cancer (TC).
Methods: Based on large-scale genome-wide association study (GWAS) data, we utilized the two-sample Mendelian randomization (MR) approach to evaluate causal relationships between periodontitis and urological cancers. Several MR methods covering various consistency assumptions were applied in this study, including contamination mixture and Robust Adjusted Profile Score to obtain robust results. Summary-level data of individuals with European ancestry were extracted from the UK Biobank, the Kaiser GERA cohorts, and the FinnGen consortium.
Results: Our findings revealed significant positive genetic correlations between periodontitis and kidney cancer (OR 1.287; 95% CI 1.04, 1.594; P = 0.020). We did not find a significant association of periodontitis on prostate cancer, bladder cancer, and testis cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on periodontitis (all P > 0.05).
Conclusion: Our study provides the evidence of a potential causal relationship between periodontitis and kidney cancer. However, large-scale studies are warranted to confirm and elucidate the underlying mechanisms of this association.
(© 2023. The Author(s).)
Databáze: MEDLINE
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