Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis.

Autor:	Costas-Carrera A; Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain., Verdolini N; Department of Mental Health, Umbria 1 Mental Health Center, Perugia, Italy., Garcia-Rizo C; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Mezquida G; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Department of Basic Clinical Practice, Pharmacology Unit, University of Barcelona, Barcelona, Spain., Janssen J; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain., Valli I; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Institute of Psychiatry Psychology and Neuroscience, King's College London, UK., Corripio I; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Psychiatry, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Sanchez-Torres AM; Department of Psychiatry, Navarra University Hospital, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Bioque M; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Lobo A; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Medicine and Psychiatry, University of Zaragoza, Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain., Gonzalez-Pinto A; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Psychiatry, Hospital Universitario de Alava, UPV/EHU, BIOARABA, Spain., Rapado-Castro M; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain.; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia., Vieta E; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Institute of Neurosciences, Barcelona, Spain., De la Serna H; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Spain., Mane A; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Hospital del Mar Medical Research Institute (IMIM), Pompeu Fabra University, Barcelona, Spain., Roldan A; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Psychiatry, Institut d'Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Crossley N; Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile.; Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile., Penades R; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Cuesta MJ; Department of Psychiatry, Navarra University Hospital, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Parellada M; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain., Bernardo M; Barcelona Clínic Schizophrenia Unit (BCSU), Neuroscience Institute, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en red de salud Mental (CIBERSAM), Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2024 May; Vol. 54 (7), pp. 1339-1349. Date of Electronic Publication: 2023 Nov 28.
DOI:	10.1017/S0033291723003185
Abstrakt:	Background: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods: We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis-Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results: FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions: Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
Databáze:	MEDLINE
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