Safety and efficacy of SARS-CoV-2 vaccination in patients with immune thrombocytopenia: A two-centre review.

Autor: Stefani S; Imperial College Healthcare NHS Trust, London, UK.; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Buti N; Imperial College Healthcare NHS Trust, London, UK., Hart ACJ; Imperial College Healthcare NHS Trust, London, UK.; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Paul D; Imperial College Healthcare NHS Trust, London, UK., Rizvi N; Imperial College Healthcare NHS Trust, London, UK., Ragoonanan V; Imperial College Healthcare NHS Trust, London, UK., Vladescu C; Imperial College Healthcare NHS Trust, London, UK., Szydlo R; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK., Ademokun C; Imperial College Healthcare NHS Trust, London, UK., Jansen AJG; Department of Haematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Cooper N; Imperial College Healthcare NHS Trust, London, UK.; Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2024 Jan; Vol. 204 (1), pp. 324-328. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1111/bjh.19212
Abstrakt: Multiple studies have reported immune thrombocytopenia (ITP) relapse following SARS-CoV-2 vaccination, however baseline ITP relapse rate and antibody response to vaccination are not known. Patients with ITP who received at least one of the first three SARS-CoV-2 vaccination doses were included in the study. One hundred and twenty-four patients met the inclusion criteria. Relapse rate was 4.2% following a first vaccine dose, 9.1% after a second and 2.9% after a third; baseline relapse rate was 7.6%. Ninety-four per cent of patients who received three vaccine doses developed a clinical antibody response. SARS-CoV-2 vaccination appears to be safe and effective in patients with ITP.
(© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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