Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.

Autor:	Nagai Y; Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Kirino E; Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan.; Department of Psychiatry, Juntendo University Shizuoka Hospital, 1129 Nagaoka Izunokuni-shi Shizuoka 410-2295, Japan.; Juntendo Institute of Mental Health, 700-1 Fukuroyama Koshigaya-shi Saitama 343-0032, Japan., Tanaka S; Department of Information and Communication Sciences, Sophia University, 7-1 Kioi-cho Chiyoda-ku Tokyo 102-8554, Japan., Usui C; Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Inami R; Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Inoue R; Juntendo Institute of Mental Health, 700-1 Fukuroyama Koshigaya-shi Saitama 343-0032, Japan., Hattori A; Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Uchida W; Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Kamagata K; Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan., Aoki S; Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku Tokyo 113-8421, Japan.; Faculty of Health Data Science, Juntendo University, 6-8-1 Hinode Urayasu-shi Chiba 279-0013, Japan.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 May 02; Vol. 34 (13), pp. 129-145.
DOI:	10.1093/cercor/bhad451
Abstrakt:	We evaluated functional connectivity (FC) in patients with adult autism spectrum disorder (ASD) using resting-state functional MRI (rs-fMRI) and diffusion kurtosis imaging (DKI). We acquired rs-fMRI data from 33 individuals with ASD and 33 healthy controls (HC) and DKI data from 18 individuals with ASD and 17 HC. ASD showed attenuated FC between the right frontal pole (FP) and the bilateral temporal fusiform cortex (TFusC) and enhanced FC between the right thalamus and the bilateral inferior division of lateral occipital cortex, and between the cerebellar vermis and the right occipital fusiform gyrus (OFusG) and the right lingual gyrus, compared with HC. ASD demonstrated increased axial kurtosis (AK) and mean kurtosis (MK) in white matter (WM) tracts, including the right anterior corona radiata (ACR), forceps minor (FM), and right superior longitudinal fasciculus (SLF). In ASD, there was also a significant negative correlation between MK and FC between the cerebellar vermis and the right OFusG in the corpus callosum, FM, right SLF and right ACR. Increased DKI metrics might represent neuroinflammation, increased complexity, or disrupted WM tissue integrity that alters long-distance connectivity. Nonetheless, protective or compensating adaptations of inflammation might lead to more abundant glial cells and cytokine activation effectively alleviating the degeneration of neurons, resulting in increased complexity. FC abnormality in ASD observed in rs-fMRI may be attributed to microstructural alterations of the commissural and long-range association tracts in WM as indicated by DKI. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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