Associations of sleep duration and daytime sleepiness with plasma amyloid beta and cognitive performance in cognitively unimpaired, middle-aged and older African Americans.

Autor:	Cook JD; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA., Malik A; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA., Plante DT; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Norton D; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Langhough Koscik R; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Du L; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Bendlin BB; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Kirmess KM; C2N Diagnostics, St. Louis, MO, USA., Holubasch MS; C2N Diagnostics, St. Louis, MO, USA., Meyer MR; C2N Diagnostics, St. Louis, MO, USA., Venkatesh V; C2N Diagnostics, St. Louis, MO, USA., West T; C2N Diagnostics, St. Louis, MO, USA., Verghese PB; C2N Diagnostics, St. Louis, MO, USA., Yarasheski KE; C2N Diagnostics, St. Louis, MO, USA., Thomas KV; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Carlsson CM; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Asthana S; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Johnson SC; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Gleason CE; Madison VA GRECC, William S. Middleton Memorial Hospital, Madison, WI, USA.; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA., Zuelsdorff M; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.; School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2024 Jan 11; Vol. 47 (1).
DOI:	10.1093/sleep/zsad302
Abstrakt:	Study Objectives: Given the established racial disparities in both sleep health and dementia risk for African American populations, we assess cross-sectional and longitudinal associations of self-report sleep duration (SRSD) and daytime sleepiness with plasma amyloid beta (Aβ) and cognition in an African American (AA) cohort. Methods: In a cognitively unimpaired sample drawn from the African Americans Fighting Alzheimer's in Midlife (AA-FAiM) study, data on SRSD, Epworth Sleepiness Scale, demographics, and cognitive performance were analyzed. Aβ40, Aβ42, and the Aβ42/40 ratio were quantified from plasma samples. Cross-sectional analyses explored associations between baseline predictors and outcome measures. Linear mixed-effect regression models estimated associations of SRSD and daytime sleepiness with plasma Aβ and cognitive performance levels and change over time. Results: One hundred and forty-seven participants comprised the cross-sectional sample. Baseline age was 63.2 ± 8.51 years. 69.6% self-identified as female. SRSD was 6.4 ± 1.1 hours and 22.4% reported excessive daytime sleepiness. The longitudinal dataset included 57 participants. In fully adjusted models, neither SRSD nor daytime sleepiness is associated with cross-sectional or longitudinal Aβ. Associations with level and trajectory of cognitive test performance varied by measure of sleep health. Conclusions: SRSD was below National Sleep Foundation recommendations and daytime sleepiness was prevalent in this cohort. In the absence of observed associations with plasma Aβ, poorer self-reported sleep health broadly predicted poorer cognitive function but not accelerated decline. Future research is necessary to understand and address modifiable sleep mechanisms as they relate to cognitive aging in AA at disproportionate risk for dementia. Clinical Trial Information: Not applicable. (© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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