Extreme Reticulocytosis After Splenectomy in a Patient With Hemoglobin Mizuho.
| Autor: | Narvestad-Bøttger H; Department of Clinical Genetics., Winther-Larsen A; Department of Clinical Biochemistry and Clinical Medicine., Haugbølle Bjerre J; Department of Pathology., Dziegiel MH; Department of Immunology, Copenhagen University Hospital, Denmark., Hansen AT; Department of Immunology, Copenhagen University Hospital, Denmark., Hasle H; Department of Pediatrics and Adolescent Medicine and Department of Clinical Medicine, Aarhus University Hospital, Aarhus. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2024 Jan 01; Vol. 46 (1), pp. e111-e114. Date of Electronic Publication: 2023 Nov 24. |
| DOI: | 10.1097/MPH.0000000000002790 |
| Abstrakt: | Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×10 9 /L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases. Competing Interests: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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