SNP array genomic analysis of matched pairs of brain and liver metastases in primary colorectal cancer.

Autor: Brandt VP; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Saxony, Germany. Vivian.Brandt@medizin.uni-leipzig.de.; Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Saxony, Germany. Vivian.Brandt@medizin.uni-leipzig.de., Holland H; Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Saxony, Germany., Wallenborn M; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Saxony, Germany.; Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Saxony, Germany., Koschny R; Interdisciplinary Endoscopy Center (IEZ), Department of Gastroenterology and Hepatology, University Hospital Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany., Frydrychowicz C; Paul Flechsig Institute of Neuropathology, University Medicine Leipzig, Leipzig, Saxony, Germany., Richter M; Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Saxony, Germany., Holland L; Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Saxony, Germany., Nestler U; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Saxony, Germany., Sander C; Department of Neurosurgery, University Hospital Leipzig, Leipzig, Saxony, Germany.
Jazyk: angličtina
Zdroj: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Dec; Vol. 149 (20), pp. 18173-18183. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1007/s00432-023-05505-4
Abstrakt: Purpose: Brain metastasis formation is a rare and late event in colorectal cancer (CRC) patients and associated with poor survival. In contrast to other metastatic sites, the knowledge on chromosomal aberrations in brain metastases is very limited.
Methods: Therefore, we carried out single nucleotide polymorphism (SNP) array analyses on matched primary CRC and brain metastases of four patients as well as on liver metastases of three patients.
Results: Brain metastases showed more chromosomal aberrations than primary tumors or liver metastases. Commonly occurring aberrations were gain of 8q11.1-q24.3 (primary CRC), gain of 13q12.13-q12.3 (liver metastases), and gain of 20q11.1-q13.33 (brain metastases). Furthermore, we found one copy-neutral loss of heterozygosity (cn-LOH) region on chromosome 3 in primary CRC, three cn-LOH regions in liver metastases and 23 cn-LOH regions in brain metastases, comprising 26 previously undescribed sites.
Conclusion: The more frequent occurrence of cn-LOHs and subsequently affected genes in brain metastases shed light on the pathophysiology of brain metastasis formation. Further pairwise genetic analyses between primary tumors and their metastases will help to define the role of affected genes in cn-LOH regions.
(© 2023. The Author(s).)
Databáze: MEDLINE
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