Antibacterial copper-filled TiO 2 coating of cardiovascular implants to prevent infective endocarditis-A pilot study.

Autor: Beltsios E; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Zubarevich A; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Ruemke S; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Rubalskii E; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Osswald A; Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany., Arjomandi Rad A; Medical Sciences Division, University of Oxford, Oxford, UK., Heidenau F; BioCer GmbH, Bayreuth, Germany., Buer J; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Hanke J; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Schmitto J; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Popov AF; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Kuehn C; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Schmack B; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Ruhparwar A; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Weymann A; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Jazyk: angličtina
Zdroj: Artificial organs [Artif Organs] 2024 Apr; Vol. 48 (4), pp. 356-364. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1111/aor.14688
Abstrakt: Background: Infective endocarditis (IE) poses a significant health risk, especially in patients with prosthetic heart valves. Despite advances in treatment, mortality rates remain high. This study aims to investigate the antibacterial properties of a copper titanium dioxide (4× Cu-TiO 2 ) coating on cardiovascular implants against Staphylococcus aureus, a common causative agent of IE.
Methods: Titanium oxide carriers functionalized with copper ions were employed as an antibacterial coating for heart and vascular prostheses. The coating's antibacterial efficacy was assessed using S. aureus ATCC 29213. Microscopic evaluations were conducted on both biological and artificial materials. Antibacterial activity was qualitatively assessed via a modified disc diffusion method and quantitatively measured through colony counts in NaCl suspensions.
Results: The coating process was successfully applied to all tested cardiovascular prosthetic materials. Qualitative assessments of antibacterial effectiveness revealed an absence of bacterial growth in the area directly beneath the coated valve. Quantitative evaluations showed a significant reduction in bacterial colonization on coated mechanical valves, with 2.95 × 10 4 CFU per valve, compared to 1.91 × 10 5 CFU in control valves.
Conclusions: The 4× Cu-TiO 2 coating demonstrated promising antibacterial properties against S. aureus, suggesting its potential as an effective strategy for reducing the risk of bacterial colonization of cardiovascular implants. Further studies are needed to assess the longevity of the coating and its efficacy against other pathogens.
(© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)
Databáze: MEDLINE
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