Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals.

Autor:	Mancini IAD; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands., Levato R; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., Ksiezarczyk MM; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., Castilho MD; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands., Chen M; Department of Mathematical Sciences, University of Adelaide, Adelaide, Australia., van Rijen MHP; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands., IJsseldijk LL; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., Kik M; Division of Pathology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., van Weeren PR; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands., Malda J; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.; Regenerative Medicine Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Orthopedics, University Medical Centre Utrecht, Utrecht, Netherlands.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Nov 27; Vol. 12. Date of Electronic Publication: 2023 Nov 27.
DOI:	10.7554/eLife.80936
Abstrakt:	During evolution, animals have returned from land to water, adapting with morphological modifications to life in an aquatic environment. We compared the osteochondral units of the humeral head of marine and terrestrial mammals across species spanning a wide range of body weights, focusing on microstructural organization and biomechanical performance. Aquatic mammals feature cartilage with essentially random collagen fiber configuration, lacking the depth-dependent, arcade-like organization characteristic of terrestrial mammalian species. They have a less stiff articular cartilage at equilibrium with a significantly lower peak modulus, and at the osteochondral interface do not have a calcified cartilage layer, displaying only a thin, highly porous subchondral bone plate. This totally different constitution of the osteochondral unit in aquatic mammals reflects that accommodation of loading is the primordial function of the osteochondral unit. Recognizing the crucial importance of the microarchitecture-function relationship is pivotal for understanding articular biology and, hence, for the development of durable functional regenerative approaches for treatment of joint damage, which are thus far lacking. Competing Interests: IM, RL, MK, MC, MC, Mv, LI, MK, Pv, JM No competing interests declared (© 2023, Mancini et al.)
Databáze:	MEDLINE
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