Intracellular negative feedback mechanisms in blubber and muscle moderate acute stress responses in fasting seals.
| Autor: | Avalos JG; Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA., Piotrowski ER; Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA., Northey AD; Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USA., Crocker DE; Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USA., Khudyakov JI; Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of experimental biology [J Exp Biol] 2023 Dec 15; Vol. 226 (24). Date of Electronic Publication: 2023 Dec 18. |
| DOI: | 10.1242/jeb.246694 |
| Abstrakt: | Animals may limit the cost of stress responses during key life history stages such as breeding and molting by reducing tissue sensitivity to energy-mobilizing stress hormones (e.g. cortisol). We measured expression of genes encoding glucocorticoid receptor (GR, NR3C1), GR inhibitor (FKBP5) and cortisol-inactivating enzyme (HSD11B2) in blubber and muscle of northern elephant seals before and after stress axis stimulation by adrenocorticotropic hormone (ACTH) early and late in a fasting period associated with molting. ACTH elevated cortisol levels for >24 h and increased FKBP5 and HSD11B2 expression while downregulating NR3C1 expression in blubber and muscle, suggesting robust intracellular negative feedback in peripheral tissues. This feedback was maintained over prolonged fasting, despite differences in baseline cortisol and gene expression levels between early and late molt, suggesting that fasting-adapted animals use multiple tissue-specific, intracellular negative feedback mechanisms to modulate downstream impacts of acute stress responses during key life history stages. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2023. Published by The Company of Biologists Ltd.) |
| Databáze: | MEDLINE |
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