Recent Advances in NIR or X-ray Excited Persistent Luminescent Materials for Deep Bioimaging.

Autor: Liu Y; School of Material Science and Engineering, University of Jinan, Jinan, China., Li J; School of Material Science and Engineering, University of Jinan, Jinan, China. mse_lijk@ujn.edu.cn.; Infovision Optoelectronics (Kunshan)Co, Ltd, Kunshan, 215300, China. mse_lijk@ujn.edu.cn., Xiahou J; School of Material Science and Engineering, University of Jinan, Jinan, China. mse_xiahoujq@ujn.edu.cn., Liu Z; School of Material Science and Engineering, University of Jinan, Jinan, China. liuzm@ujn.edu.cn.
Jazyk: angličtina
Zdroj: Journal of fluorescence [J Fluoresc] 2023 Nov 27. Date of Electronic Publication: 2023 Nov 27.
DOI: 10.1007/s10895-023-03513-8
Abstrakt: Due to their persistent luminescence, persistent luminescent (PersL) materials have attracted great interest. In the biomedical field, the use of persistent luminescent nanoparticles (PLNPs) eliminates the need for continuous in situ excitation, thereby avoiding interference from tissue autofluorescence and significantly improving the signal-to-noise ratio (SNR). Although persistent luminescence materials can emit light continuously, the luminescence intensity of small-sized nanoparticles in vivo decays quickly. Early persistent luminescent nanoparticles were mostly excited by ultraviolet (UV) or visible light and were administered for imaging purposes through ex vivo charging followed by injection into the body. Limited by the low in vivo penetration depth, UV light cannot secondary charge PLNPs that have decayed in vivo, and visible light does not penetrate deep enough to reach deep tissues, which greatly limits the imaging time of persistent luminescent materials. In order to address this issue, the development of PLNPs that can be activated by light sources with superior tissue penetration capabilities is essential. Near-infrared (NIR) light and X-rays are widely recognized as ideal excitation sources, making persistent luminescent materials stimulated by these two sources a prominent area of research in recent years. This review describes NIR and X-ray excitable persistent luminescence materials and their recent advances in bioimaging.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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