Neuroimaging Findings in Fetal Hemimegalencephaly: Case Study and Review.
| Autor: | Sepulveda W; FETALMED-Maternal-Fetal Diagnostic Center, Fetal Imaging Unit, Santiago, Chile., Sepulveda F; FETALMED-Maternal-Fetal Diagnostic Center, Fetal Imaging Unit, Santiago, Chile.; Department of Radiology, Clinica Alemana, Santiago, Chile.; Department of Neuroradiology, Institute of Neurosurgery 'Dr. Alfonso Asenjo', National Health Service, Santiago, Chile., Schonstedt V; Department of Radiology, Clinica Alemana, Santiago, Chile., Stern J; FETALMED-Maternal-Fetal Diagnostic Center, Fetal Imaging Unit, Santiago, Chile., Diaz-Serani R; Maternal-Fetal Medicine Unit, Department of Obstetrics and Gynecology, Clinica BUPA, Santiago, Chile. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Fetal diagnosis and therapy [Fetal Diagn Ther] 2024; Vol. 51 (2), pp. 133-144. Date of Electronic Publication: 2023 Nov 25. |
| DOI: | 10.1159/000535406 |
| Abstrakt: | Background: Limited information exists in the prenatal literature regarding the neuroimaging features of fetal hemimegalencephaly. Summary: This report describes ultrasound and magnetic resonance imaging (MRI) findings in a second-trimester fetus with an isolated, severe form of hemimegalencephaly. The most prominent imaging findings included unilateral enlarged cerebral hemisphere and ipsilateral ventriculomegaly causing cerebral asymmetry, midline shift, and macrocephaly. Abnormal cortical development imaging signs were also evident. A literature review encompassing 23 reports describing 36 cases, including ours, is presented. Key Messages: Characteristic ultrasound findings for the diagnosis of hemimegalencephaly are not always apparent prenatally. Asymmetric ventriculomegaly emerges as the most common but nonspecific presenting feature during routine second- or third-trimester ultrasound scans. Subsequent high-resolution prenatal neurosonography and fetal MRI facilitate definitive prenatal diagnosis, showcasting associated features primarily related to cortical migration, differentiation, and maturation. Postnatally, the prognosis is poor due to intractable seizures, hemiplegia, and progressive neurodevelopmental delay. (© 2023 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|