Polygenic risk scores associate with blood pressure traits across the lifespan.

Autor:	Øvretveit K; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway., Ingeström EML; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Spitieris M; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway.; Department of Mathematical Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Wade KH; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 1TH, UK.; Population Health Science, Bristol Medical School, Bristol BS8 1TH, UK.; Avon Longitudinal Study of Parents and Children, Bristol BS8 1TH, UK., Thomas LF; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Wolford BN; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway., Wisløff U; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Gudbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Brumpton BM; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway., Hveem K; K.G. Jebsen Centre for Genetic Epidemiology, Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Postboks 8905, N-7491 Trondheim, Norway.; Department of Innovation and Research, St. Olavs Hospital, Trondheim, Norway.
Jazyk:	angličtina
Zdroj:	European journal of preventive cardiology [Eur J Prev Cardiol] 2024 Apr 18; Vol. 31 (6), pp. 644-654.
DOI:	10.1093/eurjpc/zwad365
Abstrakt:	Aims: Hypertension is a major modifiable cause of morbidity and mortality that affects over 1 billion people worldwide. Blood pressure (BP) traits have a strong genetic component that can be quantified with polygenic risk scores (PRSs). To date, the performance of BP PRSs has mainly been assessed in adults, and less is known about polygenic hypertension risk in childhood. Methods and Results: Multiple PRSs for systolic BP (SBP), diastolic BP (DBP), and pulse pressure were developed using either genome-wide significant weights, pruning and thresholding, or Bayesian regression. Among 87 total PRSs, the top performer for each trait was applied in independent cohorts of children and adult to assess genotype-phenotype associations and disease risk across the lifespan. Differences between those with low (1st decile), average (2nd-9th decile), and high (10th decile) PRS emerge in the first years of life and are maintained throughout adulthood. These diverging BP trajectories also seem to affect cardiovascular and renal disease risk, with increased risk observed among those in the top decile and reduced risk among those in the bottom decile of the polygenic risk distribution compared with the rest of the population. Conclusion: Genetic risk factors are associated with BP traits across the lifespan, beginning in the first years of life. Given the importance of exposure time in disease pathogenesis and the early rise in BP levels among those genetically susceptible, PRSs may help identify high-risk individuals prior to hypertension onset, facilitate primordial prevention, and reduce the burden of this public health challenge. Competing Interests: Conflict of interest: V.T., D.F.G., H.H., and K.S. declare competing financial interests as employees of deCODE genetics/Amgen Inc. (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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