Dietary nitrate, nitrite, and nitrosamine in association with diabetes: a systematic review and meta-analysis.

Autor:	Nguyen NN; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Tran LTD; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Ho NDK; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Huynh LBP; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Nguyen HS; Department of Pediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.; Intensive Care Unit Department, Children's Hospital 1, Ho Chi Minh City, Viet Nam., Chen YC; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.; Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Jazyk:	angličtina
Zdroj:	Nutrition reviews [Nutr Rev] 2024 Nov 01; Vol. 82 (11), pp. 1473-1481.
DOI:	10.1093/nutrit/nuad148
Abstrakt:	Context: Diabetes is a global health concern, and diet is a contributing factor to diabetes. Findings regarding the connection between nitrate, nitrite, and nitrosamine and diabetes risk are inconsistent. Objective: The aim was to examine the effects of these dietary compounds on diabetes risk. Data Sources: The data were sourced from PubMed, EMBASE, Scopus, and Web of Science until February 28, 2023. Studies that reported individual-level consumption of these compounds were included. Review articles or ecological studies were excluded. Data Extraction: The number of events and total observations were recorded. Data Analysis: The pooled odds ratio (OR) was calculated and displayed in a forest plot. Subgroup and sensitivity analyses were predefined. A dose-response meta-analysis was conducted to determine the exposure intervals that may increase the risk of disease. Six observational reports that met the inclusion criteria were included, involving 108 615 individuals. Participants in the highest quantile of nitrite intake had a greater risk of diabetes compared with those in the lowest quantile (OR, 1.61; 95% confidence interval [CI], 1.08-2.39; I2 = 74%, P = 0.02). Higher nitrosamine consumption tended to increase diabetes risk (OR, 1.52; 95% CI, 0.76-3.04; I2 = 76%; P = 0.24). The relationship was stronger for type 1 (OR, 1.79; 95% CI, 1.20-2.67; I2 = 58%; P < 0.01) than for type 2 diabetes (OR, 1.42; 95% CI, 0.86-2.37; I2 = 71%; P = 0.17). Additionally, nitrite consumption had a dose-dependent association with both phenotypes. No association was found between diabetes risk and high nitrate intake (OR, 1.01; 95% CI, 0.87-1.18; I2 = 28%; P = 0.87). Conclusion: Attention should be paid to the consumption of nitrite-containing foods. Systematic Review Registration: PROSPERO registration no. CRD42023394462 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394462). (© The Author(s) 2023. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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