Acute and repeated exposures of normal human bronchial epithelial (NHBE) cells culture to particles from a coloured pyrotechnic smoke.

Autor: de Lagarde VM; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France. Electronic address: violaine.delagarde@gmail.com., Chevalier L; Université de Rouen Normandie, UNIROUEN, INSA Rouen, CNRS, GPM-UMR6634, 76000 Rouen, France., Méausoone C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Cazier F; Université du Littoral Côte d'Opale, CCM - Centre Commun de Mesures, 59 375 Dunkerque, France., Dewaele D; Université du Littoral Côte d'Opale, CCM - Centre Commun de Mesures, 59 375 Dunkerque, France., Cazier-Dennin F; Université du Littoral Côte d'Opale, EA 4492 - UCEIV - Unité de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 417, 59 375 Dunkerque, France., Janona M; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Logie C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Achard S; Université de Paris, Faculté de Pharmacie, Inserm UMR1153 - CRESS, HERA ' Health Environmental Risk Assessment ', 75005 Paris, France., André V; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Rogez-Florent T; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Monteil C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France., Corbiere C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTEUR 4651, F-76000 Rouen, France. Electronic address: cecile.corbiere@univ-rouen.fr.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Jan; Vol. 105, pp. 104327. Date of Electronic Publication: 2023 Nov 24.
DOI: 10.1016/j.etap.2023.104327
Abstrakt: Coloured pyrotechnic smokes are frequently used in the military field and occasionally by civilians, but their health hazards have been little studied. The main concern could rise from inhalation of smoke particles. Our previous study showed that acute exposure to particles from a red signalling smoke (RSS) induced an antioxidant and inflammatory responses in small airway epithelial cells. The aim of this study was to further explore the toxicity of RSS particles at a more proximal level of the respiratory tract, using normal human bronchial epithelial cells grown at the Air-Liquid Interface. Acute exposure (24 h) induced an oxidative stress that persisted 24 h post-exposure, associated with particle internalization and epithelium morphological changes (cuboidal appearance and loss of cilia). Repeated exposures (4×16h) to RSS particles did not trigger oxidative stress but cell morphological changes occurred. Overall, this study provides a better overview of the toxic effects of coloured smoke particles.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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