Imaging the Tumor Antioxidant Response with [ 18 F]FSPG PET.

Autor: Timmermand OV; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Witney TH; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK. tim.witney@kcl.ac.uk.
Jazyk: angličtina
Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2729, pp. 233-249.
DOI: 10.1007/978-1-0716-3499-8_14
Abstrakt: (4S)-4-(3-[ 18 F]Fluoropropyl)-L-glutamic acid ([ 18 F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [ 18 F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system x c - , whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [ 18 F]FSPG tissue retention to the intracellular redox response via system x c - activity. We herein describe the use of [ 18 F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.
(© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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