A 4-year study of bovine reproductive hormones that are induced by pharmaceuticals and appear as steroid estrogenic pollutants in the resulting slurry, using in vitro and instrumental analytical methods.

Autor: Gubó E; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary. gubo.eduard@gmail.com.; reAgro Research and Development Ltd., Győrújbarát, Hungary. gubo.eduard@gmail.com., Plutzer J; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary., Molnár T; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary., Pordán-Háber D; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary.; reAgro Research and Development Ltd., Győrújbarát, Hungary., Szabó L; Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, Geographical Institute, Budapest, Hungary., Szalai Z; Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, Geographical Institute, Budapest, Hungary., Gubó R; SynCat@Beijing, Synfuels China Technology Co. Ltd., Leyuan South Street II, No.1, Huairou District, Beijing, 101407, China.; National Energy Center for Coal to Liquids, Synfuels China Co., Ltd., Beijing, 101400, China., Szakál P; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary., Szakál T; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary., Környei L; Department of Mathematics and Computational Sciences, Széchenyi István University, Győr, Hungary., Bede-Fazekas Á; Department of Environmental and Landscape Geography, Eötvös Lóránd University, Budapest, Hungary., Kalocsai R; Albert Kázmér Faculty, Széchenyi István University, Vár Tér 2, 9200, Mosonmagyaróvár, Hungary.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Dec; Vol. 30 (60), pp. 125596-125608. Date of Electronic Publication: 2023 Nov 25.
DOI: 10.1007/s11356-023-31126-y
Abstrakt: The main objective of the research was to study the environmental "price" of the large-scale, milk production from a rarely known perspective, from the mapping of the estrogenic footprint (the amount of oestrus-inducer hormonal products, and the generated endoestrogens) in the resulting slurry in a dairy cow farm. These micropollutants are endocrine-disrupting chemicals (EDCs) and can be dangerous to the normal reproductive functions even at ng/kg concentration. One of them, 17ß-estradiol, has a 20,000 times stronger estrogenic effect than bisphenol-A, a widely known EDC of industrial origin. While most studies on EDCs are short-term and/or laboratory based, this study is longitudinal and field-based. We sampled the slurry pool on a quarterly basis between 2017 and 2020. Our purpose was testing the estrogenic effects using a dual approach. As an effect-based, holistic method, we developed and used the YES (yeast estrogen screen) test employing the genetically modified Saccharomyces cerevisiae BJ3505 strain which contains human estrogenic receptor. For testing exact molecules, UHPLC-FLD was used. Our study points out that slurry contains a growing amount of EDCs with the risk of penetrating into the soil, crops and the food chain. Considering the Green Chemistry concept, the most benign ways to prevent of the pollution of the slurry is choosing appropriate oestrus-inducing veterinary pharmaceuticals (OIVPs) and the separation of the solid and liquid parts with adequate treatment methods. To our knowledge, this is the first paper on the adaptation of the YES test for medicine and slurry samples, extending its applicability. The adapted YES test turned out to be a sensitive, robust and reliable method for testing samples with potential estrogenic effect. Our dual approach was successful in evaluating the estrogenic effect of the slurry samples.
(© 2023. The Author(s).)
Databáze: MEDLINE
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