| Autor: |
Borka Balas R; Department of Pediatrics I, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology, Gheorghe Marinescu Street, No. 38, 540136 Târgu Mureș, Romania., Meliț LE; Department of Pediatrics I, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology, Gheorghe Marinescu Street, No. 38, 540136 Târgu Mureș, Romania., Lupu A; Department of Pediatrics, University of Medicine and Pharmacy Gr. T. Popa Iași, Universității Street No 16, 700115 Iași, Romania., Lupu VV; Department of Pediatrics, University of Medicine and Pharmacy Gr. T. Popa Iași, Universității Street No 16, 700115 Iași, Romania., Mărginean CO; Department of Pediatrics I, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology, Gheorghe Marinescu Street, No. 38, 540136 Târgu Mureș, Romania. |
| Jazyk: |
angličtina |
| Zdroj: |
Microorganisms [Microorganisms] 2023 Oct 28; Vol. 11 (11). Date of Electronic Publication: 2023 Oct 28. |
| DOI: |
10.3390/microorganisms11112651 |
| Abstrakt: |
Childhood obesity is a major public health problem worldwide with an increasing prevalence, associated not only with metabolic syndrome, insulin resistance, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD), but also with psychosocial problems. Gut microbiota is a new factor in childhood obesity, which can modulate the blood lipopolysaccharide levels, the satiety, and fat distribution, and can ensure additional calories to the host. The aim of this review was to assess the differences and the impact of the gut microbial composition on several obesity-related complications such as metabolic syndrome, NAFLD, or insulin resistance. Early dysbiosis was proven to be associated with an increased predisposition to obesity. Depending on the predominant species, the gut microbiota might have either a positive or negative impact on the development of obesity. Prebiotics, probiotics, and synbiotics were suggested to have a positive effect on improving the gut microbiota and reducing cardio-metabolic risk factors. The results of clinical trials regarding probiotic, prebiotic, and synbiotic administration in children with metabolic syndrome, NAFLD, and insulin resistance are controversial. Some of them ( Lactobacillus rhamnosus bv-77 , Lactobacillus salivarius , and Bifidobacterium animalis ) were proven to reduce the body mass index in obese children, and also improve the blood lipid content; others ( Bifidobacterium bifidum , Bifidobacterium longum , Lactobacillus acidophilus , Lacticaseibacillus rhamnosus , Enterococcus faecium , and fructo-oligosaccharides) failed in proving any effect on lipid parameters and glucose metabolism. Further studies are necessary for understanding the mechanism of the gut microbiota in childhood obesity and for developing low-cost effective strategies for its management. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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