| Autor: |
Lamparelli EP; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Marino M; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Szychlinska MA; Faculty of Medicine and Surgery, Kore University of Enna, Cittadella Universitaria, 94100 Enna, Italy., Della Rocca N; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Ciardulli MC; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Scala P; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., D'Auria R; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Testa A; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', 81100 Caserta, Italy., Viggiano A; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy., Cappello F; Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy.; Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy., Meccariello R; Department of Movement and Wellbeing Sciences, Parthenope University of Naples, 80133 Naples, Italy., Della Porta G; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy.; Research Centre for Biomaterials BIONAM, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy., Santoro A; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy.; Research Centre for Biomaterials BIONAM, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy. |
| Abstrakt: |
Plastics have changed human lives, finding a broad range of applications from packaging to medical devices. However, plastics can degrade into microscopic forms known as micro- and nanoplastics, which have raised concerns about their accumulation in the environment but mainly about the potential risk to human health. Recently, biodegradable plastic materials have been introduced on the market. These polymers are biodegradable but also bioresorbable and, indeed, are fundamental tools for drug formulations, thanks to their transient ability to pass through biological barriers and concentrate in specific tissues. However, this "other side" of bioplastics raises concerns about their toxic potential, in the form of micro- and nanoparticles, due to easier and faster tissue accumulation, with unknown long-term biological effects. This review aims to provide an update on bioplastic-based particles by analyzing the advantages and drawbacks of their potential use as components of innovative formulations for brain diseases. However, a critical analysis of the literature indicates the need for further studies to assess the safety of bioplastic micro- and nanoparticles despite they appear as promising tools for several nanomedicine applications. |
