| Autor: |
Gamba M; Institute of Social and Preventive Medicine (I.S.P.M.), University of Bern, 3012 Bern, Switzerland.; Graduate School for Health Sciences, University of Bern, 3012 Bern, Switzerland., Pano O; Institute of Social and Preventive Medicine (I.S.P.M.), University of Bern, 3012 Bern, Switzerland.; Navarra Institute for Health Research (IdiSNA), 31009 Pamplona, Spain., Raguindin PF; Faculty of Health Sciences and Medicine, University of Lucerne, 6005 Lucerne, Switzerland., Roa-Diaz ZM; Medical Library, University of Bern, 3012 Bern, Switzerland.; Instituto Proinapsa, Universidad Industrial de Santander, Bucaramanga 680002, Colombia., Muka T; Institute of Social and Preventive Medicine (I.S.P.M.), University of Bern, 3012 Bern, Switzerland.; Epistudia, 3008 Bern, Switzerland., Glisic M; Institute of Social and Preventive Medicine (I.S.P.M.), University of Bern, 3012 Bern, Switzerland.; Swiss Paraplegic Research, 6207 Nottwil, Switzerland., Franco OH; Institute of Social and Preventive Medicine (I.S.P.M.), University of Bern, 3012 Bern, Switzerland.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital (C.H.U.V.) and University of Lausanne, 1011 Lausanne, Switzerland. |
| Abstrakt: |
Dietary phytochemical intake associations with cardiovascular health and mortality remain unknown. We studied the relations between total dietary phytochemical intake and cardiovascular health outcomes in a middle-aged Swiss population. We analyzed data spanning 2009 to 2021 from a prospective cohort study in Lausanne, Switzerland, including 3721 participants (54.8% women, 57.2 ± 10.3 years) without cardiovascular disease (CVD) history. Dietary intake was assessed using a validated self-reported food frequency questionnaire. The Dietary Phytochemical Index (DPI) and the healthy Dietary Phytochemical Index (hDPI) were calculated as the total energy intake percentage obtained from phytochemical-rich food consumption. The Healthy Plant-Based Diet Index (hPBD) was estimated by scoring healthy plant foods positively and less-healthy plant foods negatively. Indices tertiles and cardiometabolic outcome associations were determined using Cox proportional hazard models. Over 30,217 person-years of follow-up, 262 CVD events, and 178 deaths occurred. Unadjusted analyses found 36%, 33%, and 32% lower CVD risk for the highest hDPI, DPI, and hPBD tertiles, respectively. After adjustment, only the second hDPI tertile showed a 30% lower CVD risk (HR 0.70, 95% CI 0.51-0.95; P for trend 0.362). No other associations emerged. In this middle-aged Swiss cohort, no associations between dietary indices reflecting a phytochemical-rich dietary pattern and incident CVD, all-cause, or CVD mortality were observed. |
