Exploring the Role of Biomarkers Associated with Alveolar Damage and Dysfunction in Idiopathic Pulmonary Fibrosis-A Systematic Review.

Autor:	Zamfir AS; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Department of Medical Sciences III, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Zabara ML; Department of Surgery, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Clinic of Surgery (II), St. Spiridon Emergency Hospital, 700111 Iasi, Romania., Arcana RI; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Doctoral School of the Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Cernomaz TA; Department of Medical Sciences III, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Regional Institute of Oncology, 700483 Iasi, Romania., Zabara-Antal A; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Doctoral School of the Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Marcu MTD; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Department of Medical Sciences I, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Trofor A; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Department of Medical Sciences III, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Zamfir CL; Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Crișan-Dabija R; Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania.; Department of Medical Sciences III, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2023 Nov 14; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 14.
DOI:	10.3390/jpm13111607
Abstrakt:	Background: Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive forms of interstitial lung diseases (ILDs), marked by an ongoing, chronic fibrotic process within the lung tissue. IPF leads to an irreversible deterioration of lung function, ultimately resulting in an increased mortality rate. Therefore, the focus has shifted towards the biomarkers that might contribute to the early diagnosis, risk assessment, prognosis, and tracking of the treatment progress, including those associated with epithelial injury. Methods: We conducted this review through a systematic search of the relevant literature using established databases such as PubMed, Scopus, and Web of Science. Selected articles were assessed, with data extracted and synthesized to provide an overview of the current understanding of the existing biomarkers for IPF. Results: Signs of epithelial cell damage hold promise as relevant biomarkers for IPF, consequently offering valuable support in its clinical care. Their global and standardized utilization remains limited due to a lack of comprehensive information of their implications in IPF. Conclusions: Recognizing the aggressive nature of IPF among interstitial lung diseases and its profound impact on lung function and mortality, the exploration of biomarkers becomes pivotal for early diagnosis, risk assessment, prognostic evaluation, and therapy monitoring.
Databáze:	MEDLINE
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