Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer's Disease-A Systematic Review.

Autor: Aurelian S; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; Gerontology and Geriatrics Clinic Division, St. Luca Hospital for Chronic Illnesses, 041915 Bucharest, Romania., Ciobanu A; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; Department of Psychiatry, 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry, 041914 Bucharest, Romania., Cărare R; Faculty of Medicine, University of Southampton, Southampton SO16 7NS, UK., Stoica SI; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania.; Faculty of Midwifery and Nursing, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania., Anghelescu A; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania.; Faculty of Midwifery and Nursing, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania., Ciobanu V; Computer Science Department, Politehnica University of Bucharest, 060042 Bucharest, Romania., Onose G; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Munteanu C; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania.; Faculty of Medical Bioengineering, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iași, Romania., Popescu C; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Andone I; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Spînu A; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Firan C; NeuroRehabilitation Compartment, The Physical and Rehabilitation Medicine & Balneology Clinic Division, Teaching Emergency Hospital of the Ilfov County, 022104 Bucharest, Romania., Cazacu IS; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Trandafir AI; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Băilă M; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Postoiu RL; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; NeuroRehabilitation Clinic Division, Teaching Emergency Hospital 'Bagdasar-Arseni', 041915 Bucharest, Romania., Zamfirescu A; Faculty of Medicine, University of Medicine and Pharmacy 'Carol Davila', 020022 Bucharest, Romania.; Gerontology and Geriatrics Clinic Division, St. Luca Hospital for Chronic Illnesses, 041915 Bucharest, Romania.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 20; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 20.
DOI: 10.3390/ijms242216533
Abstrakt: One of the most complex and challenging developments at the beginning of the third millennium is the alarming increase in demographic aging, mainly-but not exclusively-affecting developed countries. This reality results in one of the harsh medical, social, and economic consequences: the continuously increasing number of people with dementia, including Alzheimer's disease (AD), which accounts for up to 80% of all such types of pathology. Its large and progressive disabling potential, which eventually leads to death, therefore represents an important public health matter, especially because there is no known cure for this disease. Consequently, periodic reappraisals of different therapeutic possibilities are necessary. For this purpose, we conducted this systematic literature review investigating nonpharmacological interventions for AD, including their currently known cellular and molecular action bases. This endeavor was based on the PRISMA method, by which we selected 116 eligible articles published during the last year. Because of the unfortunate lack of effective treatments for AD, it is necessary to enhance efforts toward identifying and improving various therapeutic and rehabilitative approaches, as well as related prophylactic measures.
Databáze: MEDLINE
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