| Autor: |
't Hart DC; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., van der Vlag J; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Nijenhuis T; Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 16; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 16. |
| DOI: |
10.3390/ijms242216419 |
| Abstrakt: |
Excessive activation of the immune system is the cause of a wide variety of renal diseases. However, the pathogenic mechanisms underlying the aberrant activation of the immune system in the kidneys often remain unknown. TRPC6, a member of the Ca 2+ -permeant family of TRPC channels, is important in glomerular epithelial cells or podocytes for the process of glomerular filtration. In addition, TRPC6 plays a crucial role in the development of kidney injuries by inducing podocyte injury. However, an increasing number of studies suggest that TRPC6 is also responsible for tightly regulating the immune cell functions. It remains elusive whether the role of TRPC6 in the immune system and the pathogenesis of renal inflammation are intertwined. In this review, we present an overview of the current knowledge of how TRPC6 coordinates the immune cell functions and propose the hypothesis that TRPC6 might play a pivotal role in the development of kidney injury via its role in the immune system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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