Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.

Autor: Cai M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Bai XL; University of Chinese Academy of Sciences, Beijing 100049, China.; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Zang HJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Tang XH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Wan JJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Peng MY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Liang H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo F; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhao PJ; School of Life Sciences, Yunnan University, Kunming 650091, China., Liao X; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Di YT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China., Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 11; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 11.
DOI: 10.3390/ijms242216196
Abstrakt: Six new C-20 and one new C-19 quassinoids, named perforalactones F-L ( 1 - 7 ), were isolated from twigs of Harrisonia perforata . Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson's disease model of PINK1 B9 . Perforalactones G and I ( 2 and 4 ) showed a 10-15% increase in cell viability of the model cells at 50 μM, while compounds 2 and 4 (100 μM) significantly improved the climbing ability of PINK1 B9 flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.
Databáze: MEDLINE
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