A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland.

Autor: De Luca P; Otolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy., Di Stadio A; Otolaryngology Unit, University of Catania, 95131 Catania, Italy., de Campora L; Otolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy., De Bonis E; Otolaryngology Unit, San Giovanni di Dio e Ruggi D'Aragona Hospital, 84131 Salerno, Italy., Fermi M; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Petruzzi G; Department Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy., Atturo F; Otolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy., Colangeli R; Otolaryngology Department, Sant'Eugenio Hospital, 00144 Rome, Italy., Scarpa A; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy., Lo Manto A; Otolaryngology Department, University of Modena and Reggio Emilia, 41121 Modena, Italy., Colizza A; Department of Sense Organs, University Sapienza, 00161 Rome, Italy., Cintoli G; Otolaryngology Unit, University of Foggia, 71122 Foggia, Italy., Togo G; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples 'Federico II', 80100 Naples, Italy., Salzano G; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples 'Federico II', 80100 Naples, Italy., Crescenzi D; Otolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy., Ralli M; Department of Sense Organs, University Sapienza, 00161 Rome, Italy., Abbate V; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples 'Federico II', 80100 Naples, Italy., Ricciardiello F; Otolaryngology Unit, AORN Cardarelli, 80131 Naples, Italy., Magaldi L; Otolaryngology Unit, University of Foggia, 71122 Foggia, Italy., D'Ecclesia A; Maxillofacial and Otolaryngology Unit, IRCCS 'Casa Sollievo della Sofferenza' San Giovanni Rotondo, 71013 Foggia, Italy., di Massa G; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy., Costarelli L; Department of Pathology, San Giovanni Addolorata-Hospital, 00184 Rome, Italy., Merenda E; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy., Corsi A; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy., Covello R; Department of Pathology, IRCCS-Regina Elena National Cancer Institute, 00144 Rome, Italy., Di Crescenzo RM; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, 80131 Naples, Italy., Duda L; Pathology Unit, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy., Dimitri LM; Department of Pathology, IRCCS 'Casa Sollievo della Sofferenza' San Giovanni Rotondo, 71013 Foggia, Italy., Caputo A; Pathology Unit, San Giovanni di Dio e Ruggi D'Aragona University Hospital, 84131 Salerno, Italy., Ferrara G; Department of Pathology, INT-IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Lucante T; Department of Pathology, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy., Longo F; Maxillofacial and Otolaryngology Unit, IRCCS 'Casa Sollievo della Sofferenza' San Giovanni Rotondo, 71013 Foggia, Italy., Tassone D; Otolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy., Iemma M; Otolaryngology Unit, San Giovanni di Dio e Ruggi D'Aragona Hospital, 84131 Salerno, Italy., Cassano M; Otolaryngology Unit, University of Foggia, 71122 Foggia, Italy., Salzano FA; Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy., Califano L; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples 'Federico II', 80100 Naples, Italy., Marchioni D; Otolaryngology Department, University of Modena and Reggio Emilia, 41121 Modena, Italy., Pellini R; Department Otolaryngology Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), 00144 Rome, Italy., de Vincentiis M; Department of Sense Organs, University Sapienza, 00161 Rome, Italy., Presutti L; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Ionna F; Maxillofacial Unit, INT-IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., de Campora E; Associazione Ospedaliera Italia Centro-Meridionale Otorinolaringoiatrica (AOICO), 00100 Rome, Italy., Radici M; Otolaryngology Department, Fatebenefratelli Isola Tiberina-Gemelli Isola, 00186 Rome, Italy., Camaioni A; Otolaryngology Department, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Nov 17; Vol. 15 (22). Date of Electronic Publication: 2023 Nov 17.
DOI: 10.3390/cancers15225456
Abstrakt: Background: The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, a subgroup of this tumor presents an aggressive behavior with a tendency to recur. The aim of this multicenter study was to identify and stratify those patients with AciCC at high risk of tumor recurrence.
Methods: A retrospective study was carried out involving 77 patients treated with surgery between January 2000 and September 2022, in different Italian referral centers. Data about tumor characteristics and its recurrence were collected. The histological specimens and slides were independently reviewed by a senior pathologist coordinator (L.C.) and the institution's local head and neck pathologist.
Results: The patients' age average was 53.6 years, with a female prevalence in the group. The mean follow-up was 67.4 months (1-258, SD 59.39). The five-year overall survival (OS) was 83.2%. The 5-year disease-free survival (DFS) was 60% (95% CI 58.2-61.7). A high incidence of necrosis, extraglandular spread, lymphovascular invasion (LVI), atypical mitosis, and cellular pleomorphism was observed in the high-risk tumors compared to the low-risk ones.
Conclusion: AciCC generally had an indolent behavior, optimal OS, DFS with few cervical node metastases, and rare distant relapses. This multicenter retrospective case series provides evidence of the need for clinical-epidemiological-histological stratification for patients at risk of poor outcomes. Our results suggest that the correct definition of high-risk AciCC should include tumor size, the presence of necrosis, extraglandular spread, LVI, atypical mitosis, and cellular pleomorphism.
Databáze: MEDLINE
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