The epidemiology of Helicobacter pylori resistance in a university affiliated hospital: a comparison between two time periods-a cross-sectional design.

Autor: Shmuely H; Department of Internal Medicine D, and Helicobacter Research Institute, Kaplan Medical Center, Rehovot, Israel. hshmuely@zahav.net.il.; Faculty of Medicine, Hebrew University, Jerusalem, Israel. hshmuely@zahav.net.il., Shvartsman Y; Department of Internal Medicine D, and Helicobacter Research Institute, Kaplan Medical Center, Rehovot, Israel.; Faculty of Medicine, Hebrew University, Jerusalem, Israel., Berdinstein R; Microbiology Laboratory, Kaplan Medical Center, Rehovot, Israel.; Faculty of Medicine, Hebrew University, Jerusalem, Israel., Yahav J; Faculty of Medicine, Hebrew University, Jerusalem, Israel., Melzer E; Faculty of Medicine, Hebrew University, Jerusalem, Israel.; Department of Gastroenterology, Kaplan Medical Center, Rehovot, Israel.
Jazyk: angličtina
Zdroj: European journal of medical research [Eur J Med Res] 2023 Nov 24; Vol. 28 (1), pp. 538. Date of Electronic Publication: 2023 Nov 24.
DOI: 10.1186/s40001-023-01500-0
Abstrakt: Purpose: During the last few decades, the increased use of various types of antibiotics in the general population caused a significant change in regional Helicobacter pylori (H. pylori) antibiotic resistance. Our aim is to study the changes in H. pylori resistance in patients who had undergone an esophagogastroduodenoscopy (EGD) and susceptibility testing and found positive for H. pylori. The study was conducted in a university affiliated hospital between 2013-2020.
Methods: A cross-sectional study was performed on all consecutive patients who had undergone an EGD and tested positive for H. pylori at the Kaplan Medical Center, Israel. The study period was divided into two sub-periods: 2013-2016 and 2017-2020. Data on age, sex, comorbidities, previous treatments, and antimicrobial susceptibility testing for six antimicrobial agents were compared.
Results: The resistance rates of H. pylori to clarithromycin and dual resistance to clarithromycin and metronidazole were found significantly higher during the late period. Multivariable analysis showed that the later period, older age, and diabetes mellitus were independent predictors for antimicrobial resistance.
Conclusions: Our study has shown that there is an increasing resistance of H. pylori to clarithromycin and metronidazole while its susceptibility is unaffected with time to other antibiotics. More recent cross-sectional studies with larger samples are warranted in order to evaluate the changes in the resistance patterns of H. pylori to various antibiotics with time.
(© 2023. The Author(s).)
Databáze: MEDLINE
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