The Effectiveness of Topical Dimethicone Together with a One Health Approach for the Control of Tungiasis in the Sanumás Communities, Yanomami Territory, Amazon Rainforest: A Real-World Study.

Autor:	Santana YRT; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil.; Secretaria Especial de Saúde Indígena (SESAI), Ministério da Saúde do Brasil, Brasília 70723-040, Brazil.; Programa de Pós-Graduação em Saúde Coletiva, Universidade de Brasília, Brasília 70910-900, Brazil., Andrade DDBC; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil., Barroso DH; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil., Silva AV; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil., Oliveira LFC; Secretaria Especial de Saúde Indígena (SESAI), Ministério da Saúde do Brasil, Brasília 70723-040, Brazil., Timbó RV; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil., Araújo DD; Dimensuri Assessoria Técnica, Brasília 70391-900, Brazil., de Andrade RR; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil., Pellegrini MA; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Roraima, Boa Vista 69304-000, Brazil., de Carvalho FCA; Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Roraima, Boa Vista 69304-000, Brazil., Martins LPF; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília 70910-900, Brazil., Gomes CM; Programa de Pós-Graduação em Ciências Médicas, Universidade de Brasília, Brasília 70910-900, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Universidade de Brasília, Brasília 70910-900, Brazil.
Jazyk:	angličtina
Zdroj:	Tropical medicine and infectious disease [Trop Med Infect Dis] 2023 Oct 30; Vol. 8 (11). Date of Electronic Publication: 2023 Oct 30.
DOI:	10.3390/tropicalmed8110489
Abstrakt:	Background: The success of tungiasis treatment is highly dependent on adequate environmental control. Methods: This is a real-world observational cohort study designed to monitor the effectiveness of topical dimethicone together with a One Health approach for the control of tungiasis in the Sanumás communities, Amazon rainforest, Brazil. We followed up on 562 indigenous people and 81 domestic dogs for 1.5 years in a 3-month interval. A new molecular method for large-scale soil evaluation was also tested. The control of tungiasis was independently conducted by the Brazilian Ministry of Health and comprised topical dimethicone application (NYDA ® ) for humans, single-dose oral afoxolaner for dogs, and in-house soil fumigation with fipronil. The main outcome was the occurrence of tungiasis after the use of topical dimethicone together with the One Health approach. Results: A total of 49 of the 562 indigenous people had active tungiasis at enrollment (8.72%). Only three cases of tungiasis resulted in active lesions after the use of topical dimethicone together with the One Health approach, with two cases of recurrence. From the 6-month follow-up and after, soil infestation was not detected. Conclusions: We conclude that the use of NYDA ® together with animal and environmental interventions are effective measures for the control of tungiasis.
Databáze:	MEDLINE
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