Diffusion-weighted magnetic resonance imaging in early central retinal artery occlusion.

Autor:	Lange KS; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Neurology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Mourand I; Department of Neurology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Coget A; Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Menjot de Champfleur N; Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.; I2FH, Institut d'Imagerie Fonctionnelle Humaine, Hôpital Gui de Chauliac, CHRU de Montpellier, Montpellier, France., Ayrignac X; Department of Neurology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Arquizan C; Department of Neurology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Scheel M; Institute for Neuroradiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bohner G; Institute for Neuroradiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Villringer K; Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Berlin, Germany., Zagroun C; Department of Ophthalmology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France., Siebert E; Institute for Neuroradiology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Danyel LA; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	European stroke journal [Eur Stroke J] 2023 Dec; Vol. 8 (4), pp. 974-981. Date of Electronic Publication: 2023 Aug 01.
DOI:	10.1177/23969873231190716
Abstrakt:	Introduction: Restricted retinal diffusion (RDR) has recently been recognized as a frequent finding on standard diffusion-weighted imaging (DWI) in central retinal artery occlusion (CRAO). However, data on early DWI signal evolution are missing. Patients and Methods: Consecutive CRAO patients with DWI performed within 24 h after onset of visual impairment were included in a bicentric, retrospective cross-sectional study. Two blinded neuroradiologists assessed randomized DWI scans for the presence of retinal ischemia. RDR detection rates, false positive ratings, and interrater agreement were evaluated for predefined time groups. Results: Sixty eight CRAO patients (68.4 ± 16.8 years; 25 female) with 72 DWI scans (76.4% 3 T, 23.6% 1.5 T) were included. Mean time-delay between onset of CRAO and DWI acquisition was 13.4 ± 7.0 h. Overall RDR detection rates ranged from 52.8% to 62.5% with false positive ratings in 4.2%-8.3% of cases. RDR detection rates were higher in DWI performed 12-24 h after onset, when compared with DWI acquired within the first 12 h (79.5%vs 39.3%, p  < 0.001). The share of false positive ratings was highest for DWI performed within the first 6 h of symptom onset (up to 14.3%). Interrater reliability was "moderate" for DWI performed within the first 18 h (κ = 0.57-0.58), but improved for DWI acquired between 18 and 24 h (κ = 0.94). Conclusion: DWI-based detection of retinal ischemia in early CRAO is likely to be time-dependent with superior diagnostic accuracy for DWI performed 12-24 h after onset of visual impairment. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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