Assembly and optically triggered disassembly of lipid-DNA origami fibers.

Autor:	Julin S; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi., Best N; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi.; Technische Universität Darmstadt, 64289 Darmstadt, Germany.; Fraunhofer Institute for Microengineering and Microsystems IMM, 55129 Mainz, Germany., Anaya-Plaza E; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi., Enlund E; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi., Linko V; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi.; Institute of Technology, University of Tartu, 50411 Tartu, Estonia., Kostiainen MA; Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland. mauri.kostiainen@aalto.fi.; LIBER Center of Excellence, Aalto University, 00076 Aalto, Finland.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Dec 12; Vol. 59 (99), pp. 14701-14704. Date of Electronic Publication: 2023 Dec 12.
DOI:	10.1039/d3cc04677j
Abstrakt:	The co-assembly of lipids and other compounds has recently gained increasing interest. Here, we report the formation of stimuli-responsive lipid-DNA origami fibers through the electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades when exposed to UV-A light, which allows a photoinduced, controlled release of the 6HBs from the fibers. The presented complexation strategy may find uses in developing responsive nanomaterials e.g. for therapeutics.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu