Virus-Induced Cell Fusion and Syncytia Formation.
| Autor: | Xie M; Division of Infection and Immunity, UCL, London, UK. maorong.xie@ucl.ac.uk. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Results and problems in cell differentiation [Results Probl Cell Differ] 2024; Vol. 71, pp. 283-318. |
| DOI: | 10.1007/978-3-031-37936-9_14 |
| Abstrakt: | Most enveloped viruses encode viral fusion proteins to penetrate host cell by membrane fusion. Interestingly, many enveloped viruses can also use viral fusion proteins to induce cell-cell fusion, both in vitro and in vivo, leading to the formation of syncytia or multinucleated giant cells (MGCs). In addition, some non-enveloped viruses encode specialized viral proteins that induce cell-cell fusion to facilitate viral spread. Overall, viruses that can induce cell-cell fusion are nearly ubiquitous in mammals. Virus cell-to-cell spread by inducing cell-cell fusion may overcome entry and post-entry blocks in target cells and allow evasion of neutralizing antibodies. However, molecular mechanisms of virus-induced cell-cell fusion remain largely unknown. Here, I summarize the current understanding of virus-induced cell fusion and syncytia formation. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|