Hydroxyapatite particle shape affects screw attachment in cancellous bone when augmented with hydroxyapatite-containing hydrogels.

Autor: Zhou Y; Division of Biomedical Engineering, Department of Materials Science and Engineering, Uppsala University, Sweden., Höglund L; Division of Macromolecular Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden., Samanta A; Division of Macromolecular Chemistry, Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden., Procter P; Division of Biomedical Engineering, Department of Materials Science and Engineering, Uppsala University, Sweden., Persson C; Division of Biomedical Engineering, Department of Materials Science and Engineering, Uppsala University, Sweden. Electronic address: cecilia.persson@angstrom.uu.se.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Feb; Vol. 150, pp. 106241. Date of Electronic Publication: 2023 Nov 15.
DOI: 10.1016/j.jmbbm.2023.106241
Abstrakt: Screw-bone construct failures are a true challenge in orthopaedic implant fixation, particularly in poor quality bone. Whilst augmentation with bone cement can improve the primary stability of screws, there are cements, e.g. PMMA, that may impede blood flow and nutrients and hamper bone remodelling. In this study, soft, non-setting biomaterials based on Hyalectin gels and hydroxyapatite (HA) particles with different morphological parameters were evaluated as potential augmentation materials, using a lapine ex vivo bone model. The pull-out force, stiffness, and work to fracture were considered in evaluating screw attachment. The pull-out force of constructs reinforced with Hyalectin containing irregularly shaped nano-HA and spherically shaped micro-HA particles were found to be significantly higher than the control group (no augmentation material). The pull-out stiffness increased for the micro-HA particles and the work to fracture increased for the irregular nano-HA particles. However, there were no significant augmentation effect found for the spherical shaped nano-HA particles. In conclusion, injectable Hyalectin gel loaded with hydroxyapatite particles was found to have a potentially positive effect on the primary stability of screws in trabecular bone, depending on the HA particle shape and size.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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