REM parameters in drug-free major depressive disorder: A systematic review and meta-analysis.

Autor: Arıkan MK; Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey. Electronic address: mkarikan46@gmail.com., Uysal Ö; Istanbul University Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Biostatistics, Istanbul, Turkey., Gıca Ş; Department of Mental Health and Disease, MERAM School of Medicine, Necmettin Erbakan University, Konya, Turkey., Orhan Ö; Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey., İlhan R; Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey., Esmeray MT; Kemal Arıkan Psychiatry Clinic, Istanbul, Turkey., Bakay H; Department of Mental Health and Disease, MERAM School of Medicine, Necmettin Erbakan University, Konya, Turkey., Metin B; Department of Neurology, Medical Faculty, Uskudar University, Istanbul, Turkey., Pogarell O; Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Munich, Germany., Turan Ş; Istanbul University Cerrahpasa, Department of Psychiatry, Cerrahpasa Medical School, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Sleep medicine reviews [Sleep Med Rev] 2024 Feb; Vol. 73, pp. 101876. Date of Electronic Publication: 2023 Nov 20.
DOI: 10.1016/j.smrv.2023.101876
Abstrakt: Previous studies revealed that rapid eye movement (REM) parameters, such as REM latency (RL) and REM density (RD) could be used as electrophysiological markers of depression. Yet these finding should be re-tested in a comorbid-free and drug-free sample. The present systematic review and meta-analysis was conducted to investigate whether drug-free and comorbid-free patients with unipolar depression differentiate from controls with respect to the RL and RD. The PubMed and Web of Science databases were screened from inception to 23 January 2023 for case-control studies comparing RL and RD of patients with unipolar depression and controls. The primary outcome was the standard mean difference. The data were fitted with a random-effects model. Meta-regressions were conducted to investigate patient characteristics and effect size. Publication bias assessment was checked by Egger's Regression and funnel plot asymmetry. Among 43 articles accepted as eligible, 46 RL and 22 RD measurements were included in the meta-analysis. The results indicated shortened RL and increased RD in the patient group than controls. Neither Egger's regression nor funnel plot asymmetry were significant for publication bias. In conclusion, our results tested within drug-free and comorbid-free samples are in line with the literature.
Competing Interests: Declaration of competing interest None declared.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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