Patient-Reported Outcomes of Accelerated Aging: A Novel Approach to Investigate Second Cancer Risk in Adolescent and Young Adult (18-39 Years) Cancer Survivors.

Autor:	van der Meer DJ; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, North Holland, The Netherlands.; Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands., Zevenbergen S; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, North Holland, The Netherlands.; Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands., Vlooswijk C; Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, Utrecht, The Netherlands., Bijlsma RM; Department of Medical Oncology, University Medical Center, Utrecht, Utrecht, The Netherlands., Kaal SEJ; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, Gelderland, The Netherlands., Kerst JM; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, North Holland, The Netherlands., Tromp JM; Department of Medical Oncology, Amsterdam University Medical Centers, Amsterdam, North Holland, The Netherlands., Bos MEMM; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, South Holland, The Netherlands., van der Hulle T; Department of Medical Oncology, Leiden University Medical Center, Leiden, South Holland, The Netherlands., Lalisang RI; Department of Internal Medicine, Division of Medical Oncology, GROW-School of Oncology and Reproduction, Maastricht UMC+ Comprehensive Cancer Center, Maastricht, Limburg, The Netherlands., Nuver J; Department of Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands., Kouwenhoven MCM; Department of Neurology, Amsterdam University Medical Centers, Amsterdam, North Holland, The Netherlands.; Cancer Center Amsterdam, Cancer treatment and quality of life, Amsterdam, North Holland, The Netherlands., van der Graaf WTA; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, North Holland, The Netherlands.; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, South Holland, The Netherlands., Husson O; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, North Holland, The Netherlands.; Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.; Department of Surgical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, South Holland, The Netherlands.
Jazyk:	angličtina
Zdroj:	The oncologist [Oncologist] 2024 Apr 04; Vol. 29 (4), pp. e526-e534.
DOI:	10.1093/oncolo/oyad307
Abstrakt:	Background: Adolescent and young adult cancer survivors (AYAs, aged 18-39 years at first diagnosis) have a higher second cancer risk. Accelerated aging is hypothesized as underlying mechanism and has been described clinically by 6 indicators; fatigue, low quality of sleep, low mood, lack of motivation, subjective memory complaints, and poor exercise tolerance. Using patient-reported outcomes, we aimed to identify clusters of accelerated aging among AYA cancer survivors and to investigate their association with second cancer development. Patients and Methods: Patient, tumor, and treatment data were obtained from the Netherlands Cancer Registry. Patient-reported clinical indicators and second cancer data were obtained from the SURVivors (5-20 years) of cancer in AYAs (SURVAYA) questionnaire study between 1999 and 2015. Latent class and multivariable logistic regression analyses were performed. Results: In total, n = 3734 AYA survivors with known second cancer status (n = 278 [7.4%] second cancers) were included. Four latent clusters were identified and named based on their clinical indicator features; (1) high accelerated aging (31.3%), (2) intermediate accelerated aging without poor exercise tolerance (15.1%), (3) intermediate accelerated aging without lack of motivation (27.4%), and (4) low accelerated aging (26.2%). AYAs in the high accelerated aging cluster were more likely to have second cancer (odds ratio: 1.6; 95% CI, 1.1-2.3) compared to the low accelerated aging cluster. Conclusion: AYAs with a higher burden of accelerated aging were more likely to develop a second cancer. Validation of the clinical indicators and how to best capture them is needed to improve (early) detection of AYAs at high risk of developing second cancer. (© The Author(s) 2023. Published by Oxford University Press.)
Databáze:	MEDLINE
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