Effects of Cognitive Training on Alzheimer's Disease and Related Dementias: The Moderating Role of Social Determinants of Health.

Autor:	Rebok GW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA.; Johns Hopkins Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA., Gellert A; TIAA Institute, New York, NY, USA., Coe NB; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clay OJ; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.; Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA., Wallace G; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA., Parisi JM; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA., Aiken-Morgan AT; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA., Crowe M; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.; Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA., Ball K; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.; Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA., Thorpe RJ Jr; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA.; Johns Hopkins Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA.; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Marsiske M; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA., Zahodne LB; Department of Psychology, University of Michigan, Ann Arbor, MI, USA., Felix C; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Willis SL; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Jazyk:	angličtina
Zdroj:	Journal of aging and health [J Aging Health] 2023 Oct; Vol. 35 (9_suppl), pp. 40S-50S.
DOI:	10.1177/08982643231203755
Abstrakt:	Objective: We examined whether social determinants of health (SDoH) are associated with Alzheimer's disease and related dementias (ADRD) risk and the effects of cognitive training over a 20-year follow-up period. Methods: Data were obtained from 1605 participants in ACTIVE. SDoH measures were created using baseline data at the individual and neighborhood level. Incident ADRD was defined using administrative claims data (1999-2019). Cause-specific hazard models estimated associations between SDoH and claims-based diagnosed ADRD. Results: Higher scores on neighborhood and built environment were associated with lower ADRD risk. Trained participants obtained a greater degree of protection from ADRD when they had higher scores for SDoH domains associated with health care and education access. However, there were fewer significant SDoH moderation effects on cognitive training than expected. Discussion: Future work should continue to explore culturally tailored cognitive training interventions to reduce ADRD risk associated with SDoH that disproportionately affects racially diverse aging populations. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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